{"id":"W4411743715","doi":"10.1002/ctm2.70380","title":"T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China","keywords":"Cancer research; Biology; Flow cytometry; T cell; Demethylating agent; Molecular biology; Immunology; DNA methylation; Genetics; Gene expression; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436837,0.000126779,0.0001474131,0.0004552784,0.0001474118,0.0003113695,0.0001258773,0.0001812293,0.001472373],"category_scores_gemma":[0.0003976365,0.0001188863,0.000104626,0.0002522057,0.0001687618,0.000136428,0.0001944691,0.0002685517,0.000316211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002753778,"about_ca_system_score_gemma":0.0001319095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477326,"about_ca_topic_score_gemma":0.0006276697,"domain_scores_codex":[0.9998395,0.00003340245,0.00001562788,0.00004280734,0.00003423326,0.00003434006],"domain_scores_gemma":[0.9997494,0.00006878027,0.00008309311,0.00002869584,0.00002110204,0.00004902456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001429701,0.0001004293,0.2034352,0.00004915911,0.00003031269,0.0008018547,0.0002144399,0.0002607038,0.7841817,0.0002603775,0.0002387834,0.008997355],"study_design_scores_gemma":[0.00008013925,0.0008705569,0.851204,0.00001263618,0.00009458989,0.006429009,0.000285164,0.001760919,0.1359748,0.0003984081,0.002875264,0.00001448114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988704,0.0001549446,0.0003952704,0.00001127396,0.000001255575,0.000009537483,0.0001844412,0.00001691062,0.0003559208],"genre_scores_gemma":[0.9993339,0.00006717609,0.0001863742,0.00001670513,0.000003776762,0.00001035953,0.0002512205,0.000007631037,0.000122844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472373,"threshold_uncertainty_score":0.004925609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0785733804514466,"score_gpt":0.3323221900926113,"score_spread":0.2537488096411646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}