{"id":"W4411743715","doi":"10.1002/ctm2.70380","title":"T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China","keywords":"Cancer research; Biology; Flow cytometry; T cell; Demethylating agent; Molecular biology; Immunology; DNA methylation; Genetics; Gene expression; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716091,0.0002118655,0.0005176619,0.0002098085,0.0000709959,0.00001324158,0.00004295648,0.0001632,0.00008937586],"category_scores_gemma":[0.0002556224,0.0001541689,0.00006081914,0.0002196154,0.0003532378,0.00006785936,0.00001941389,0.0001144593,0.000005227233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002828864,"about_ca_system_score_gemma":0.0002044687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000789548,"about_ca_topic_score_gemma":0.00004096913,"domain_scores_codex":[0.9981919,0.0001112077,0.0007675352,0.0004430195,0.0002954215,0.0001909295],"domain_scores_gemma":[0.9978054,0.001653522,0.000112457,0.0001353054,0.00009403284,0.0001993326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005092968,0.0008434218,0.9608026,0.0002749753,0.00005503724,0.0000258102,0.0002168368,0.00001099786,0.0002732784,0.001644904,0.00009868895,0.0352442],"study_design_scores_gemma":[0.01882627,0.0005426636,0.9736294,0.0004665327,0.0003022919,0.00001025202,0.00009287252,0.003809465,0.000275557,0.001115742,0.0008104549,0.0001185039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878142,0.002942037,0.0003390009,0.004423358,0.0002240553,0.0004638915,0.00001814898,0.00002700914,0.003748324],"genre_scores_gemma":[0.9967829,0.001468785,0.0003051383,0.0005785374,0.0001247225,0.00003499884,0.0001208875,0.000009390582,0.0005746234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03512569,"threshold_uncertainty_score":0.6286826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0785733804514466,"score_gpt":0.3323221900926113,"score_spread":0.2537488096411646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}