{"id":"W4411747112","doi":"10.1101/2025.06.25.661610","title":"Specificity of Aberrant Exons in a Saturated Background of Differentially Expressed Exons","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Manitoba Health","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Research Manitoba","keywords":"Exon; Genetics; Computational biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006315338,0.0002253594,0.0003224832,0.0006872641,0.000252817,0.0005564789,0.0001778864,0.0003441187,0.002098318],"category_scores_gemma":[0.001184486,0.0001744879,0.0002872638,0.0007091881,0.0003360842,0.0003001407,0.000555972,0.0003477207,0.0006298453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828965,"about_ca_system_score_gemma":0.0001501916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003215536,"about_ca_topic_score_gemma":0.0008826169,"domain_scores_codex":[0.9993604,0.00008002059,0.00008084271,0.0002573313,0.0001459342,0.00007542357],"domain_scores_gemma":[0.9991019,0.0004511497,0.0001308028,0.0001332969,0.0001273916,0.00005552751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005919132,0.0000253273,0.07448134,0.0003526773,0.0001768313,0.001091301,0.0001760296,0.001274969,0.9066043,0.0005849316,0.0003834883,0.01425694],"study_design_scores_gemma":[0.00003683293,0.0004205581,0.4883655,0.0001270734,0.0004433396,0.01030733,0.0004111755,0.01609278,0.4626613,0.002747899,0.01833908,0.00004706756],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811864,0.001264855,0.01273285,0.00007264723,0.00001582748,0.00002381912,0.002936421,0.0001415872,0.001625564],"genre_scores_gemma":[0.987866,0.0003144072,0.006143622,0.0001405133,0.00001133877,0.0000208344,0.004711289,0.00005412975,0.0007378666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098318,"threshold_uncertainty_score":0.007019579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380295559522335,"score_gpt":0.2269260878633448,"score_spread":0.2131231322681215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}