{"id":"W4411755358","doi":"10.32388/9acjg4","title":"Synuclein Aggregation: Critical Role of Water in Entropy-Driven, Temperature-Responsive Aggregations of Macromolecules and Cells","year":2025,"lang":"en","type":"preprint","venue":"Qeios","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Queen's University","keywords":"Macromolecule; Entropy (arrow of time); Statistical physics; Biophysics; Chemistry; Physics; Thermodynamics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009912781,0.0002171827,0.0005740383,0.0003307241,0.00003771398,0.00002021753,0.0001048785,0.0002346406,0.0001192992],"category_scores_gemma":[0.0002218595,0.0001677831,0.0001515438,0.0001167911,0.0002687075,0.00003952397,0.0002929607,0.0003680633,0.00001168319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007252887,"about_ca_system_score_gemma":0.0004294918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001219617,"about_ca_topic_score_gemma":0.00001515765,"domain_scores_codex":[0.9984123,0.00017355,0.0004196057,0.0003700618,0.0003581597,0.0002663173],"domain_scores_gemma":[0.9987658,0.0002223297,0.00008011289,0.0003968593,0.000350223,0.0001847145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01113653,0.009859765,0.0844787,0.01474375,0.02741322,0.004251762,0.008689602,0.0004611711,0.8040622,0.0253516,0.001567739,0.007983977],"study_design_scores_gemma":[0.002116506,0.0003836883,0.006132872,0.003189814,0.0009539687,0.000018158,0.0003735659,0.0005361012,0.9812718,0.004719959,0.00008796105,0.0002155735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98869,0.008017018,0.000007206546,0.001045198,0.0000721623,0.0009305163,0.0005476197,0.00001767841,0.0006726705],"genre_scores_gemma":[0.9981841,0.000507373,0.0007914551,0.00004237482,0.00003455196,0.0000860135,0.0002336496,0.00001538144,0.000105125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1772097,"threshold_uncertainty_score":0.6841996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085336707535502,"score_gpt":0.3002899481729684,"score_spread":0.2894365810976134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}