{"id":"W4411766116","doi":"10.1007/s00204-025-04116-x","title":"Unravelling the role of nanomedicine in attenuating inflammation, oxidative stress and cellular ageing in chronic obstructive pulmonary disease","year":2025,"lang":"en","type":"review","venue":"Archives of Toxicology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Sydney Partnership for Health, Education, Research and Enterprise; University of Technology Sydney","keywords":"Inflammation; COPD; Oxidative stress; Medicine; Lung; Senescence; Pathogenesis; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004514539,0.0005360372,0.0008233355,0.001423493,0.0002715453,0.0007127802,0.0005200729,0.001137201,0.002090503],"category_scores_gemma":[0.000440789,0.0002341019,0.0004252416,0.001110703,0.0003551169,0.001254036,0.000575015,0.001589783,0.0009268537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004320825,"about_ca_system_score_gemma":0.0009405925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006421293,"about_ca_topic_score_gemma":0.001226509,"domain_scores_codex":[0.9998673,0.00002616284,0.00001613915,0.00002195704,0.00005339082,0.00001502467],"domain_scores_gemma":[0.9998031,0.00009386199,0.00002355666,0.000006045503,0.00005548002,0.00001798054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007720092,0.0001107875,0.0001804146,0.02789643,0.00009599493,0.000361722,0.0001454279,0.0005952001,0.01182717,0.008464203,0.02058429,0.9296611],"study_design_scores_gemma":[0.00001412387,0.0001852882,0.0006986731,0.003030267,0.00008434741,0.001388065,0.00007714736,0.0002159726,0.002265414,0.002770986,0.9892496,0.00002013081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002219593,0.9983107,0.0001941962,0.0002606986,0.0002106865,0.000004014004,0.000009088571,0.000005371214,0.0007832732],"genre_scores_gemma":[0.00122422,0.9975562,0.0002648252,0.0001904654,0.0001326322,0.000007546983,0.00001470582,0.000001361282,0.0006081151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002090503,"threshold_uncertainty_score":0.006993473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008655704326976389,"score_gpt":0.2694115465692776,"score_spread":0.2607558422423013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}