{"id":"W4411769365","doi":"10.1038/s12276-025-01466-5","title":"Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer","year":2025,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi; Fondation Leducq; National Institute for Health and Care Research; Medical Research Council; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Cancer Research UK","keywords":"Bromodomain; Biology; Triple-negative breast cancer; Epigenetics; Cancer research; Chromatin; Transcriptome; Histone acetyltransferase; Cancer; Genetics; Breast cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930104,0.0002619546,0.0003186398,0.0001035876,0.00007530099,0.00002187036,0.0001751877,0.0001522861,0.0002561637],"category_scores_gemma":[0.0001682583,0.0002364423,0.00006715306,0.0002654547,0.0003466132,0.000009618041,0.0001682229,0.0001543265,0.000003569853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009933682,"about_ca_system_score_gemma":0.0001211201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284195,"about_ca_topic_score_gemma":0.00005591677,"domain_scores_codex":[0.9983057,0.0001421138,0.0004119801,0.0005868028,0.0002551553,0.0002982558],"domain_scores_gemma":[0.9993393,0.00001407387,0.00009479631,0.0003440229,0.00006648231,0.0001413307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002786295,0.0001371477,0.001052196,0.00002780206,0.00005581667,0.00002062975,0.0001260729,0.000002894206,0.9961576,0.0001142674,0.001171566,0.0008554109],"study_design_scores_gemma":[0.003245535,0.0002006472,0.01294502,0.000154114,0.0000218227,0.00001660057,0.0003632476,0.00006860558,0.981556,0.0001515867,0.001059435,0.0002173656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849891,0.01116335,0.0004589615,0.001286956,0.0001730323,0.0006274976,0.00002652499,0.00001853841,0.001256011],"genre_scores_gemma":[0.9971377,0.0001017961,0.0008251992,0.001140339,0.0001093062,0.0002106939,0.00006878582,0.00002185599,0.000384271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01460155,"threshold_uncertainty_score":0.9641835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007149197330071749,"score_gpt":0.306698942011161,"score_spread":0.2995497446810892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}