{"id":"W4411769365","doi":"10.1038/s12276-025-01466-5","title":"Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer","year":2025,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi; Fondation Leducq; National Institute for Health and Care Research; Medical Research Council; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Cancer Research UK","keywords":"Bromodomain; Biology; Triple-negative breast cancer; Epigenetics; Cancer research; Chromatin; Transcriptome; Histone acetyltransferase; Cancer; Genetics; Breast cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009881114,0.0003061605,0.0003109406,0.00027558,0.0001498968,0.0002074863,0.0001884618,0.0003361284,0.001907293],"category_scores_gemma":[0.0001364493,0.0001254908,0.0002382065,0.0001902143,0.0001396531,0.0000993475,0.0001560066,0.0003800062,0.0004426854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243428,"about_ca_system_score_gemma":0.0001330313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006982324,"about_ca_topic_score_gemma":0.001590804,"domain_scores_codex":[0.9999152,0.000008189584,0.000006228424,0.00002263279,0.00003269963,0.00001505102],"domain_scores_gemma":[0.9999261,0.00001696252,0.00002319565,0.000007306149,0.000009255183,0.00001714425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004033045,0.00001171158,0.000193199,0.0000270127,0.000004306076,0.00005729178,0.000005614962,0.0001028325,0.9981865,0.00003565873,0.00004439884,0.001291052],"study_design_scores_gemma":[0.00002345853,0.0003314896,0.008644979,0.00001021344,0.00003595412,0.0008374838,0.00003318788,0.001760652,0.9840968,0.00006794759,0.004146979,0.00001094847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870434,0.001530595,0.006060863,0.0002139446,0.00003826446,0.00008699734,0.002726576,0.0004261106,0.001873253],"genre_scores_gemma":[0.9896559,0.001018601,0.00364478,0.0001355243,0.000007172611,0.00005453657,0.002326804,0.00007161051,0.003085111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907293,"threshold_uncertainty_score":0.006380498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007149197330071749,"score_gpt":0.306698942011161,"score_spread":0.2995497446810892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}