{"id":"W4411798727","doi":"10.1371/journal.ppat.1013294","title":"Complex interactions in the life cycle of a simple parasite shape the evolution of virulence","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Virulence; Biology; Host (biology); Parasite hosting; Transmission (telecommunications); Horizontal transmission; Obligate parasite; Zoology; Experimental evolution; Evolutionary biology; Ecology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005793659,0.0003514582,0.0003967915,0.0004484387,0.000383368,0.0009560211,0.0003412582,0.000522901,0.0009975652],"category_scores_gemma":[0.002055899,0.0003026293,0.0003544755,0.0002542851,0.0008501253,0.0009711324,0.0007319577,0.000512473,0.0002210357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006868201,"about_ca_system_score_gemma":0.0003258497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266999,"about_ca_topic_score_gemma":0.002623308,"domain_scores_codex":[0.9996841,0.0001389211,0.0000184257,0.00006606423,0.00004286273,0.00004956474],"domain_scores_gemma":[0.9991497,0.0003299702,0.0002539164,0.00009868632,0.00005635399,0.0001113461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004088924,0.0001768278,0.2222824,0.0003345848,0.0002872701,0.001064306,0.001200153,0.07424215,0.6102223,0.04237029,0.0006388563,0.04677206],"study_design_scores_gemma":[0.00004240883,0.000629113,0.6646552,0.00007827108,0.0002090466,0.001265678,0.001257451,0.2502108,0.02719571,0.04630106,0.007962557,0.0001927424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872231,0.0003077386,0.01015718,0.0002170722,0.000008215187,0.00001166836,0.00007320281,0.00003468494,0.00196711],"genre_scores_gemma":[0.9967307,0.0002077674,0.002748624,0.00003677261,0.000004169692,0.00001014818,0.00004038986,0.00001242131,0.0002090166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266999,"threshold_uncertainty_score":0.004983306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712829501312711,"score_gpt":0.2878339072186012,"score_spread":0.2707056122054741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}