{"id":"W4411798727","doi":"10.1371/journal.ppat.1013294","title":"Complex interactions in the life cycle of a simple parasite shape the evolution of virulence","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Virulence; Biology; Host (biology); Parasite hosting; Transmission (telecommunications); Horizontal transmission; Obligate parasite; Zoology; Experimental evolution; Evolutionary biology; Ecology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577687,0.00006693563,0.00009194101,0.00004024046,0.00005352303,0.000004597776,0.0002240275,0.00003652563,0.00002252648],"category_scores_gemma":[0.0001585907,0.0000461433,0.00006773334,0.0002057084,0.0001033783,0.000001851767,0.00006651704,0.00006661381,0.00000259911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000128845,"about_ca_system_score_gemma":0.00007928929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006342182,"about_ca_topic_score_gemma":0.0004846955,"domain_scores_codex":[0.9993384,0.0001154191,0.0002215034,0.0001293809,0.00009108929,0.000104206],"domain_scores_gemma":[0.9994631,0.00004232174,0.00008425857,0.0003205698,0.00007408694,0.00001564596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004443292,0.0002421809,0.03416559,0.00003185594,0.00005834158,3.994112e-7,0.0002524777,0.002755294,0.9586207,0.002204791,0.0009927838,0.000631213],"study_design_scores_gemma":[0.0005766447,0.0001580367,0.8516682,0.00005180683,0.0001097529,0.000005449561,0.002554636,0.1266186,0.01118968,0.001609715,0.005288266,0.0001691866],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937289,0.0003550366,0.003118707,0.0005028021,0.00003750585,0.0001753418,0.00008498671,0.000003454403,0.001993252],"genre_scores_gemma":[0.9992328,0.00005877124,0.0002201182,0.000326685,0.00002447366,0.00001898556,0.0000423976,0.000004011647,0.00007175913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.947431,"threshold_uncertainty_score":0.1881669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712829501312711,"score_gpt":0.2878339072186012,"score_spread":0.2707056122054741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}