{"id":"W4411803204","doi":"10.3390/md23070272","title":"Sequential Extraction of Bioactive Saponins from Cucumaria frondosa Viscera: Supercritical CO2–Ethanol Synergy for Enhanced Yields and Antioxidant Performance","year":2025,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Mitacs","keywords":"Saponin; Extraction (chemistry); Supercritical carbon dioxide; Chemistry; Chromatography; Ethanol; Supercritical fluid; Solvent; DPPH; Hexane; Antioxidant; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167618,0.0001678527,0.0002416666,0.00005887202,0.00009592233,0.00002353801,0.0001032764,0.0001895578,0.00004850089],"category_scores_gemma":[0.0001161281,0.0001563086,0.00009496846,0.00006628328,0.0001388758,0.00001578122,0.0001631859,0.0001126816,7.530627e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002213032,"about_ca_system_score_gemma":0.00006269974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001054464,"about_ca_topic_score_gemma":0.0001504366,"domain_scores_codex":[0.9990268,0.00004504803,0.0002252019,0.0004027151,0.00009033312,0.0002099479],"domain_scores_gemma":[0.9995014,0.00008855075,0.00003685248,0.0002374185,0.00009542338,0.00004032802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006472651,0.00007451242,0.000962548,0.00006996816,0.0001515269,4.309441e-7,0.00004911125,0.000002794522,0.9737486,0.0003328291,0.0001943375,0.02376606],"study_design_scores_gemma":[0.0006574552,0.0001799568,0.003937878,0.00003270244,0.00007602226,0.000002082569,0.0001819614,0.0004443278,0.9912553,0.0002709679,0.002792012,0.0001692646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939998,0.0002405083,0.002653233,0.0004330343,0.0003541226,0.0002357594,0.0001069846,0.00001169838,0.001964869],"genre_scores_gemma":[0.9971671,0.0004271207,0.0009908149,0.00009961579,0.000199348,0.00003467601,0.0001579003,0.00001407584,0.0009094122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02359679,"threshold_uncertainty_score":0.6374079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005803031691640161,"score_gpt":0.2511724436008966,"score_spread":0.2453694119092565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}