{"id":"W4411803204","doi":"10.3390/md23070272","title":"Sequential Extraction of Bioactive Saponins from Cucumaria frondosa Viscera: Supercritical CO2–Ethanol Synergy for Enhanced Yields and Antioxidant Performance","year":2025,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Mitacs","keywords":"Saponin; Extraction (chemistry); Supercritical carbon dioxide; Chemistry; Chromatography; Ethanol; Supercritical fluid; Solvent; DPPH; Hexane; Antioxidant; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132805,0.0006140209,0.0003791329,0.0002993026,0.0001967471,0.0002184138,0.0001524101,0.0002299989,0.0004277715],"category_scores_gemma":[0.0001260711,0.0001501576,0.0003204409,0.0002419575,0.0001839922,0.0003049847,0.0002555711,0.0003491266,0.0001885235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817894,"about_ca_system_score_gemma":0.0002666891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009394076,"about_ca_topic_score_gemma":0.004227174,"domain_scores_codex":[0.9998966,0.00001314518,0.000007620181,0.00002372775,0.00003634199,0.00002251509],"domain_scores_gemma":[0.9999387,0.00001040922,0.00001478811,0.000005484567,0.00002041057,0.00001016687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003391291,0.00000766509,0.00009375317,0.00007656225,0.000005963661,0.00004292976,0.000009636272,0.00004510879,0.9985793,0.00001371563,0.00001190713,0.001079502],"study_design_scores_gemma":[0.000005633434,0.0001571686,0.003298974,0.00001282024,0.00002173576,0.0001251983,0.00003029231,0.0005236291,0.9946516,0.0000160818,0.001148098,0.000008688547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910721,0.002670602,0.00425701,0.00006193056,0.00003381562,0.00007544101,0.0002458057,0.00004788367,0.001535379],"genre_scores_gemma":[0.9888917,0.001685255,0.007414191,0.00006670067,0.00001485049,0.00004706105,0.0003586942,0.00002302562,0.001498548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009394076,"threshold_uncertainty_score":0.00186795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005803031691640161,"score_gpt":0.2511724436008966,"score_spread":0.2453694119092565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}