{"id":"W4411803718","doi":"10.1093/inteam/vjaf082","title":"Ecotoxicological assessments of over-the-counter NSAID (diclofenac, ibuprofen, aspirin) and antipyretic (acetaminophen) pharmaceuticals: a review of their toxicity effects on aquatic crustaceans","year":2025,"lang":"en","type":"review","venue":"Integrated Environmental Assessment and Management","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministerio de Economía y Competitividad; U.S. Environmental Protection Agency","keywords":"Diclofenac; Toxicity; Acetaminophen; Antipyretic; Acute toxicity; Ecotoxicity; Ecotoxicology; Hyalella azteca; Bioassay; Biota; Pharmacology; Biology; Toxicology; Crustacean; Medicine; Ecology; Analgesic; Amphipoda; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000895402,0.001045213,0.002067502,0.0001491412,0.0001599319,0.00005096127,0.000686897,0.0002733875,0.001182981],"category_scores_gemma":[0.00002147582,0.0006330798,0.0004452037,0.0003946396,0.001154536,0.0002000732,0.001566813,0.0008093499,0.00005016647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006752982,"about_ca_system_score_gemma":0.00002660194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000171229,"about_ca_topic_score_gemma":0.000002349266,"domain_scores_codex":[0.9954831,0.0006026069,0.001313611,0.001067596,0.0008696887,0.0006633723],"domain_scores_gemma":[0.9976352,0.0007075656,0.000689091,0.0006773715,0.000003078342,0.0002876327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004044973,0.001564927,0.001301327,0.07620064,0.0008249469,0.00005395758,0.00002475579,0.000002186937,0.0004823683,0.0002191581,0.001333421,0.9179519],"study_design_scores_gemma":[0.003141374,0.002601477,0.01400171,0.20341,0.008561824,0.00005226462,0.0002775933,0.0008317278,0.00319949,0.0004095484,0.7613001,0.00221286],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01495213,0.9712375,0.0002576064,0.0001993122,0.0002805772,0.005908039,0.0003115339,0.00004470036,0.006808563],"genre_scores_gemma":[0.02625714,0.9706973,0.0003551056,0.001654402,0.00001927643,0.0002035317,0.000147444,0.00004855159,0.0006172344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.915739,"threshold_uncertainty_score":0.9997301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03094843933046828,"score_gpt":0.3698796389958239,"score_spread":0.3389311996653557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}