{"id":"W4411814605","doi":"10.1002/em.70020","title":"Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Transferability; Reproducibility; Duplex (building); Computational biology; Genetics; Chromatography; Biology; Chemistry; DNA; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02044785,0.0009085806,0.0007248254,0.001882432,0.0007181574,0.002137691,0.00150377,0.001000358,0.001898155],"category_scores_gemma":[0.03678339,0.0008669887,0.0009042611,0.001068392,0.001320303,0.001095843,0.001816935,0.00110456,0.001020886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009285848,"about_ca_system_score_gemma":0.0007173746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499586,"about_ca_topic_score_gemma":0.00260049,"domain_scores_codex":[0.9692578,0.01152864,0.003241551,0.005671259,0.009533211,0.0007675177],"domain_scores_gemma":[0.9717235,0.01252756,0.002121049,0.005889271,0.007468278,0.0002704511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003145142,0.0001664641,0.007316908,0.0002362811,0.0001002443,0.00005072309,0.0007705146,0.002837707,0.95542,0.00186573,0.0004303007,0.03049077],"study_design_scores_gemma":[0.00001593581,0.0005616441,0.008472013,0.00003386162,0.00007951387,0.0001461161,0.00009427928,0.01109627,0.9742746,0.0006814043,0.004495738,0.00004855739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4583317,0.0007828142,0.5252998,0.0002718124,0.0001760441,0.002246215,0.002130275,0.002215756,0.008545584],"genre_scores_gemma":[0.5376993,0.000813421,0.4456417,0.0003026561,0.00004847993,0.003185661,0.003492648,0.0007079759,0.008108241],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02044785,"threshold_uncertainty_score":0.1081399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006501075815676714,"score_gpt":0.2200600108136471,"score_spread":0.2135589349979704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}