{"id":"W4411823429","doi":"10.3390/cancers17132173","title":"Advancing the Landscape of Clinical Actionability in Von Hippel–Lindau Syndrome: An Evidence-Based Framework from the INT2GRATE Oncology Consortium","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Dana-Farber Cancer Institute","keywords":"Germline; Li–Fraumeni syndrome; Pheochromocytoma; Germline mutation; Medicine; Cancer; Kidney cancer; Renal cell carcinoma; Oncology; Bioinformatics; Cancer research; Internal medicine; Biology; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1336754,0.001554833,0.002067087,0.0194713,0.001621759,0.01394846,0.00622238,0.004796894,0.002528493],"category_scores_gemma":[0.2048832,0.0007746181,0.003884139,0.007704555,0.006129889,0.005797319,0.01368514,0.008243626,0.0004170984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01030223,"about_ca_system_score_gemma":0.02987554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01112578,"about_ca_topic_score_gemma":0.01859231,"domain_scores_codex":[0.9185904,0.05251285,0.01049279,0.004356248,0.01283208,0.001215571],"domain_scores_gemma":[0.7222139,0.1943453,0.02262337,0.009815051,0.04179619,0.009206329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007258353,0.0003348268,0.04031846,0.01259206,0.00344803,0.001246322,0.002179192,0.02440148,0.001243802,0.2926187,0.05631636,0.5645749],"study_design_scores_gemma":[0.0006030948,0.001369666,0.01760467,0.06266271,0.005413208,0.002132146,0.002518891,0.03803647,0.002924036,0.5260405,0.3402894,0.0004051868],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02484716,0.1887246,0.3073465,0.4263104,0.002171049,0.002297357,0.005051621,0.001032707,0.04221862],"genre_scores_gemma":[0.2988098,0.05197945,0.6043574,0.03350872,0.003115368,0.001927117,0.004645875,0.0003005456,0.001355735],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1336754,"threshold_uncertainty_score":0.7069517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902232985311996,"score_gpt":0.3665331981059078,"score_spread":0.3375108682527878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}