{"id":"W4411823524","doi":"10.3390/cancers17132199","title":"Tumour- and Non-Tumour-Associated Factors That Modulate Response to PD-1/PD-L1 Inhibitors in Non-Small Cell Lung Cancer","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Sanofi; AstraZeneca; Pfizer","keywords":"PD-L1; Immunotherapy; Biomarker; Medicine; Lung cancer; Immune system; Cancer; Antigen; Immune checkpoint; Cancer research; Tumor microenvironment; Oncology; Antibody; Cell; Atezolizumab; Durvalumab; Immunology; Internal medicine; Nivolumab; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003918979,0.000516306,0.001203086,0.001254584,0.0001166285,0.0005725051,0.000508116,0.0006723176,0.002082633],"category_scores_gemma":[0.0005155739,0.0002054076,0.0006247179,0.001200631,0.000195209,0.0006034689,0.0003704478,0.0008636013,0.0008629938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003581825,"about_ca_system_score_gemma":0.0005719371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006207787,"about_ca_topic_score_gemma":0.001535456,"domain_scores_codex":[0.9998806,0.0000260808,0.00002383378,0.00001888038,0.00003992199,0.00001068243],"domain_scores_gemma":[0.9998423,0.00008415373,0.00002900627,0.000003387316,0.00003194414,0.000009289131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001511299,0.0000767869,0.0002208665,0.04314938,0.0002663294,0.0001330755,0.00004942746,0.0003614199,0.001942129,0.001468478,0.01465872,0.9375223],"study_design_scores_gemma":[0.00009158295,0.0003975766,0.003232885,0.01495053,0.0007442578,0.001690435,0.00007278124,0.0002046953,0.001163681,0.001453857,0.9759645,0.00003323422],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001406451,0.9993675,0.00003807762,0.00007856544,0.00005619018,0.000003998934,0.00001321871,0.000002706985,0.0002990912],"genre_scores_gemma":[0.0006997802,0.9988297,0.00007077333,0.0001075525,0.00003827085,0.000007002865,0.00002316299,6.553701e-7,0.0002231139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002082633,"threshold_uncertainty_score":0.006967127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02454189587147483,"score_gpt":0.3122262527405105,"score_spread":0.2876843568690357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}