{"id":"W4411844174","doi":"10.1111/imm.70013","title":"Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal‐Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell'Università e della Ricerca; Research Nova Scotia; Regione Autonoma della Sardegna; Ministero della Salute; Dalhousie University; European Commission; Canadian Institutes of Health Research; Li Ka Shing Foundation","keywords":"T-cell receptor; Immunology; Biology; Multiple sclerosis; Antigen; Population; Immune system; T cell; Pathogenesis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008156973,0.0003579839,0.0006691051,0.0003561342,0.0002998046,0.00003017881,0.0007515503,0.0006852188,0.00012504],"category_scores_gemma":[0.0002003446,0.0002341636,0.0001276144,0.0006301907,0.0006416441,0.0001072327,0.0003403452,0.001017131,0.0001056232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001178531,"about_ca_system_score_gemma":0.00008675771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006588592,"about_ca_topic_score_gemma":0.003160934,"domain_scores_codex":[0.9963078,0.00163123,0.0008350622,0.0005137719,0.00005683318,0.0006552277],"domain_scores_gemma":[0.9976239,0.001342155,0.0003545745,0.0005937346,0.00007381009,0.00001179972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004244963,0.0004620474,0.02230347,0.0000162645,0.0001787824,0.000004124795,0.001693264,0.000008675944,0.9708224,0.001541881,0.0007759877,0.001768583],"study_design_scores_gemma":[0.004841325,0.0002537517,0.325261,0.0001214351,0.00009712233,0.00001300113,0.00199105,0.00006534957,0.6443767,0.0008412489,0.02175414,0.0003839138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832242,0.01132835,0.000005020718,0.001272925,0.00270249,0.0006776961,0.00004217906,0.00004279519,0.0007043309],"genre_scores_gemma":[0.9975471,0.0007945938,0.00003511902,0.000259244,0.00001803374,0.00007407804,0.0002015416,0.00002151586,0.001048787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3264457,"threshold_uncertainty_score":0.9960024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008896837779650241,"score_gpt":0.1947928178788697,"score_spread":0.1858959800992195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}