{"id":"W4411846582","doi":"10.3899/jrheum.2025-0314.1","title":"Macrophage Migration Inhibitory Factor and Hypoxia-Inducible Factor 1-Alpha May Play a Role in Maintaining Intestinal Homeostasis Through Regulation of Occludin and Claudin-1 Expression","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University Health Network","funders":"","keywords":"Macrophage migration inhibitory factor; Occludin; Medicine; Homeostasis; Claudin; Immunology; Hypoxia (environmental); Inhibitory postsynaptic potential; Hypoxia-inducible factors; Alpha (finance); Cell biology; Endocrinology; Cytokine; Biology; Tight junction; Biochemistry; Gene; Surgery; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005466174,0.000228156,0.0005813993,0.0003873306,0.000175271,0.00001805353,0.0001929083,0.0003113907,0.0001838348],"category_scores_gemma":[0.0004625034,0.0001663705,0.00006780832,0.0002253039,0.0003959388,0.0002795301,0.0001336441,0.0005669169,0.000005280037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001011291,"about_ca_system_score_gemma":0.000182837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002744359,"about_ca_topic_score_gemma":0.0001799831,"domain_scores_codex":[0.9977259,0.0007321602,0.0009790062,0.0002167658,0.00007872141,0.0002674478],"domain_scores_gemma":[0.9978738,0.0008730607,0.0008487644,0.000211637,0.0001642141,0.00002853092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708878,0.0000714843,0.1546663,0.00007349176,0.00008021096,0.000003542816,0.007580795,0.00001868716,0.8332266,0.0006857985,0.0004894454,0.002394816],"study_design_scores_gemma":[0.003400974,0.0005141277,0.1499227,0.000915513,0.00007027627,0.00156084,0.004918378,0.00005115354,0.8346505,0.002395253,0.001354989,0.0002452641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900735,0.007384749,0.001327511,0.0004102103,0.0004815999,0.000224484,0.00002496339,0.00001457312,0.00005843053],"genre_scores_gemma":[0.9986907,0.0005831163,0.000491893,0.00004764917,0.000008466795,0.000004776957,0.000007954663,0.00001362753,0.00015186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008617177,"threshold_uncertainty_score":0.6784393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423813532688731,"score_gpt":0.2585158821235916,"score_spread":0.2442777467967043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}