{"id":"W4411846582","doi":"10.3899/jrheum.2025-0314.1","title":"Macrophage Migration Inhibitory Factor and Hypoxia-Inducible Factor 1-Alpha May Play a Role in Maintaining Intestinal Homeostasis Through Regulation of Occludin and Claudin-1 Expression","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University Health Network","funders":"","keywords":"Macrophage migration inhibitory factor; Occludin; Medicine; Homeostasis; Claudin; Immunology; Hypoxia (environmental); Inhibitory postsynaptic potential; Hypoxia-inducible factors; Alpha (finance); Cell biology; Endocrinology; Cytokine; Biology; Tight junction; Biochemistry; Gene; Surgery; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632592,0.0003264096,0.0002572793,0.000283852,0.0002178489,0.000292504,0.0002086651,0.0003803772,0.001196248],"category_scores_gemma":[0.0001137113,0.0001376082,0.0002789164,0.0001553543,0.0002943209,0.0003255537,0.0002258873,0.0004127556,0.0001994132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002734092,"about_ca_system_score_gemma":0.0002429811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000703446,"about_ca_topic_score_gemma":0.0008926364,"domain_scores_codex":[0.9998333,0.00002311972,0.000008046394,0.00002690414,0.0000345425,0.00007397816],"domain_scores_gemma":[0.9998798,0.00000659438,0.00006054348,0.000004779252,0.00001514952,0.0000330781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008556701,0.00007742221,0.003070462,0.0002183816,0.00001760077,0.0002528385,0.00004935044,0.00007631222,0.9882491,0.0003625484,0.0002009921,0.006569394],"study_design_scores_gemma":[0.0002508621,0.007412437,0.2121152,0.0001087792,0.0002161397,0.0027813,0.000727629,0.002036592,0.7506933,0.0007344859,0.02288891,0.00003440561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773884,0.01582749,0.003455518,0.000451177,0.00006006796,0.00006995865,0.0003468312,0.0001133562,0.002287136],"genre_scores_gemma":[0.992774,0.002891011,0.001271204,0.0001237633,0.00002937647,0.00007209349,0.0002277396,0.000004765513,0.002606056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196248,"threshold_uncertainty_score":0.004001796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423813532688731,"score_gpt":0.2585158821235916,"score_spread":0.2442777467967043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}