{"id":"W4411847068","doi":"10.1186/s13071-025-06863-3","title":"Role of mast cell-derived exosomes in exacerbating neuronal injury of experimental cerebral malaria","year":2025,"lang":"en","type":"article","venue":"Parasites & Vectors","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Microvesicles; Biology; Cerebral Malaria; Plasmodium berghei; Immunology; Exosome; Inflammation; Proinflammatory cytokine; Tumor necrosis factor alpha; microRNA; Cell biology; Cancer research; Plasmodium falciparum; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008270741,0.0001549961,0.0001951308,0.00009139592,0.00002561125,0.000007901207,0.000217756,0.00009954654,0.00006458568],"category_scores_gemma":[0.00006023487,0.0001700739,0.0001047587,0.0001551414,0.0001099463,0.000006073289,0.0001609632,0.00008122793,0.00000256526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001657335,"about_ca_system_score_gemma":0.00007465795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004551869,"about_ca_topic_score_gemma":0.000008760283,"domain_scores_codex":[0.998971,0.00008716004,0.0003293626,0.0002917988,0.0001152637,0.0002054148],"domain_scores_gemma":[0.999476,0.00002539189,0.0001305081,0.0002857147,0.00003378879,0.00004864295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129171,0.0002281054,0.2655341,0.00003260015,0.00001920579,0.000001021875,0.00009582972,0.00005404549,0.7336021,0.00009793721,0.00004787423,0.0001742464],"study_design_scores_gemma":[0.0003644426,0.0001327692,0.1600389,0.00002583896,0.00001239564,5.094275e-7,0.0002924288,0.0001250982,0.838778,0.00004030174,0.00008074537,0.000108508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950782,0.00293253,0.00003979869,0.00001235666,0.00007703327,0.0001616382,0.00002409541,0.000007927218,0.001666405],"genre_scores_gemma":[0.9990481,0.00001568245,0.0006333845,0.00002753101,0.00003346187,0.00001777406,0.00005160036,0.00001813981,0.0001543118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1054952,"threshold_uncertainty_score":0.693541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004111384887044329,"score_gpt":0.2490328657931599,"score_spread":0.2449214809061156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}