{"id":"W4411848010","doi":"10.1016/s1470-2045(25)00211-6","title":"Hormone therapy use and young-onset breast cancer: a pooled analysis of prospective cohorts included in the Premenopausal Breast Cancer Collaborative Group","year":2025,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; Ontario Institute for Cancer Research","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Health Service Corps; National Institute of Environmental Health Sciences; National Cancer Institute; Centers for Disease Control and Prevention; Breast Cancer Now; California Department of Public Health; Instituto Nacional del Cáncer; Breast Cancer Research Foundation; Avon Foundation for Women; Foundation for the National Institutes of Health; American Cancer Society; U.S. Department of Health and Human Services; National Institutes of Health; Institute of Cancer Research","keywords":"Breast cancer; Medicine; Cancer; Oncology; Prospective cohort study; Internal medicine; Gynecology; Hormone therapy; Obstetrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006013321,0.001404343,0.003530291,0.001813124,0.0007125727,0.001947289,0.001208507,0.001516746,0.001252308],"category_scores_gemma":[0.006369078,0.001380719,0.009993024,0.003823614,0.000399058,0.0007707337,0.001322209,0.0009140422,0.0002004507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005670126,"about_ca_system_score_gemma":0.0008128947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02377605,"about_ca_topic_score_gemma":0.02701369,"domain_scores_codex":[0.9952334,0.002363766,0.0005302913,0.001118868,0.0003540938,0.0003994875],"domain_scores_gemma":[0.9941276,0.00165313,0.001564615,0.001728578,0.0005171741,0.0004089286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0118229,0.00006889236,0.8549545,0.0006482893,0.1239274,0.0002874629,0.0001668602,0.0005488889,0.001441659,0.0001319463,0.001353456,0.004647845],"study_design_scores_gemma":[0.001002883,0.0005571087,0.9242941,0.0001271901,0.0714827,0.000261404,0.0002817861,0.0004732035,0.0002522746,0.0001463727,0.001072927,0.00004809651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9344558,0.05602588,0.001626012,0.0002320827,0.0002940674,0.00008402488,0.006391759,0.00007713359,0.0008131756],"genre_scores_gemma":[0.9907016,0.004822711,0.0004997617,0.000125408,0.0001272618,0.00007517463,0.003095932,0.00003045811,0.0005216593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02377605,"threshold_uncertainty_score":0.0472753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450298272052199,"score_gpt":0.3158602187689554,"score_spread":0.3013572360484334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}