{"id":"W4411848522","doi":"10.1186/s12964-025-02333-6","title":"The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion","year":2025,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Agricultural University; Institute of Genetics; National Natural Science Foundation of China","keywords":"Notch signaling pathway; Histone; Signal transduction; Drosophila (subgenus); Drosophila melanogaster; Cell biology; Biology; Genetics; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006878563,0.0001099096,0.0001047141,0.00004860282,0.0003984711,0.00003017541,0.0001946703,0.0001012484,0.000004647384],"category_scores_gemma":[0.00003626617,0.00009431916,0.00003640961,0.000105889,0.0001516914,0.000007599556,0.0001614541,0.0001363497,0.000002099726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003351356,"about_ca_system_score_gemma":0.00005896838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001918067,"about_ca_topic_score_gemma":0.00007456228,"domain_scores_codex":[0.9991232,0.0002597942,0.000205581,0.0002127153,0.00005645,0.0001422441],"domain_scores_gemma":[0.999423,0.0001015745,0.00007764211,0.0003243807,0.00004653078,0.00002692739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008283424,0.00003465194,0.001843996,0.00001432257,0.00001687645,3.451416e-7,0.0002117721,0.0002909348,0.9911118,0.0005703635,0.00006346258,0.005758624],"study_design_scores_gemma":[0.001170404,0.00004891679,0.0252879,0.00007078495,0.00002024906,0.000003783267,0.0005839272,0.001376567,0.9570532,0.002173001,0.01192784,0.000283393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918136,0.004989862,0.0009777397,0.0005532599,0.00005159818,0.0001577597,0.000001898405,0.00001006452,0.001444236],"genre_scores_gemma":[0.9974333,0.00057068,0.0004818465,0.0001516388,0.00001357263,0.00002362766,0.00006777075,0.000005869186,0.00125169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03405859,"threshold_uncertainty_score":0.3846224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009259198779809122,"score_gpt":0.2689902699209287,"score_spread":0.2597310711411195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}