{"id":"W4411848849","doi":"10.1016/j.bbrep.2025.102123","title":"Comprehensive transcriptomic analysis of hepatocellular Carcinoma: Uncovering shared and unique molecular signatures across diverse etiologies","year":2025,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Research Institute for Gastroenterology and Liver Diseases; Gastrointestinal and Liver Diseases Research Center","keywords":"Hepatocellular carcinoma; Subtyping; Biology; Transcriptome; Computational biology; Epigenetics; Cancer research; Bioinformatics; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001780032,0.000471286,0.001142872,0.00289804,0.0003561524,0.001113162,0.0002724552,0.0002178714,0.0007638413],"category_scores_gemma":[0.001526009,0.0001831429,0.001569517,0.003754756,0.000260533,0.0004055262,0.0008140008,0.0003857761,0.0001598615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264299,"about_ca_system_score_gemma":0.0006994225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001806316,"about_ca_topic_score_gemma":0.003300508,"domain_scores_codex":[0.9990016,0.0003059163,0.00008986542,0.0003353628,0.0001742693,0.00009305289],"domain_scores_gemma":[0.9989395,0.000464152,0.000200816,0.0002010605,0.0001228295,0.00007182407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001205696,0.00009653953,0.7911616,0.001935299,0.01539048,0.0004749545,0.0003707397,0.004013624,0.1077915,0.0007166667,0.002346775,0.074496],"study_design_scores_gemma":[0.00003366944,0.0003175502,0.9659407,0.0002049015,0.00780686,0.0008196483,0.0005042846,0.004945198,0.007725652,0.001948112,0.009703845,0.00004957997],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9204019,0.03846683,0.01221404,0.0007549003,0.00007956659,0.00006393409,0.02591307,0.0002211288,0.001884673],"genre_scores_gemma":[0.9724845,0.005746436,0.004819714,0.0002601724,0.00005292986,0.00007008891,0.01603752,0.00005679314,0.0004718761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00289804,"threshold_uncertainty_score":0.009413838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02477024144071781,"score_gpt":0.2634752695098161,"score_spread":0.2387050280690983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}