{"id":"W4411857643","doi":"10.1093/oncolo/oyaf194","title":"Mitigation and management of adverse events associated with amivantamab therapy","year":2025,"lang":"en","type":"review","venue":"The Oncologist","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Johnson and Johnson","keywords":"Medicine; Erlotinib; Adverse effect; Rash; Oncology; Internal medicine; Epidermal growth factor receptor; Hypoalbuminemia; Chemotherapy; Paronychia; Gefitinib; Targeted therapy; Cancer; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001615917,0.0002839998,0.0005482846,0.0003860163,0.0004046257,0.0007993977,0.0004977168,0.0006684471,0.001661338],"category_scores_gemma":[0.004905422,0.00009205953,0.000487607,0.0002106505,0.0001959245,0.0005408532,0.0004380252,0.00135881,0.0005929303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004296735,"about_ca_system_score_gemma":0.0009078922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003840967,"about_ca_topic_score_gemma":0.0009308897,"domain_scores_codex":[0.9986185,0.0005798808,0.000205245,0.0000727501,0.0004410924,0.00008258963],"domain_scores_gemma":[0.9984725,0.0003712209,0.000571874,0.00006079395,0.0003812152,0.0001423292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006613903,0.0006133906,0.01356607,0.001475153,0.0001926011,0.002323446,0.0004065259,0.001543149,0.01214739,0.002639631,0.02728164,0.9371497],"study_design_scores_gemma":[0.000740017,0.008816238,0.08226497,0.004670032,0.0005911487,0.03034131,0.0008468396,0.008810448,0.04431414,0.008103308,0.8103657,0.000135945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.300567,0.3469318,0.147071,0.04605956,0.003823841,0.003542525,0.0006522148,0.002383601,0.1489685],"genre_scores_gemma":[0.792438,0.102244,0.07326152,0.01085425,0.002966197,0.001325953,0.0006902271,0.0001472154,0.01607255],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001661338,"threshold_uncertainty_score":0.008545876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691692597764053,"score_gpt":0.4025874823463018,"score_spread":0.3656705563686612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}