{"id":"W4411865936","doi":"10.1007/s12035-025-05179-8","title":"G-Protein-Coupled Receptor–Microtubule Interactions Regulate Neurite Development and Protect Against β-Amyloid Neurotoxicity","year":2025,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Neurotoxicity; Neurite; Cell biology; Microtubule; Amyloid β; Chemistry; Receptor; Amyloid (mycology); Neuroscience; Biophysics; Biochemistry; Biology; Medicine; Toxicity; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001565965,0.0003364467,0.0003101434,0.0001415735,0.0002041408,0.00003981379,0.0002756788,0.0002192174,0.00001896755],"category_scores_gemma":[0.0001208371,0.0003408629,0.0001165922,0.0001873996,0.0001782838,0.000007054697,0.0004307207,0.0002937896,0.00001588487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000167271,"about_ca_system_score_gemma":0.000105274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001192444,"about_ca_topic_score_gemma":0.00001979258,"domain_scores_codex":[0.9980624,0.0002212509,0.0003861342,0.0008044776,0.00007021879,0.0004555336],"domain_scores_gemma":[0.9991428,0.00001281792,0.0001270567,0.0005345622,0.00008967267,0.00009306909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017378,0.00005933105,0.0001068372,0.00003161044,0.00006706256,0.00001343119,0.00002177294,0.00004513622,0.991981,0.0002375563,0.000646957,0.006687581],"study_design_scores_gemma":[0.000527235,0.0001008589,0.001505221,0.00002493365,0.00001448737,0.00002204994,0.000008904714,0.00005901489,0.7337145,0.00002562126,0.2637641,0.0002330507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921619,0.0006432182,0.004013381,0.0006390064,0.000466218,0.0008993311,0.00001158798,0.0000545935,0.001110776],"genre_scores_gemma":[0.9900096,0.0001372052,0.002482836,0.003255488,0.00008034884,0.0002595008,0.0001565978,0.00004666774,0.003571748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2631171,"threshold_uncertainty_score":0.9999043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005428749889880504,"score_gpt":0.2252757853281176,"score_spread":0.2198470354382371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}