{"id":"W4411866579","doi":"10.1021/acsnano.5c08831","title":"Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Adjuvant; Immune system; Dendritic cell; Immunology; Germinal center; Antigen; Biology; Antigen-presenting cell; Follicular dendritic cells; T cell; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617357,0.0002860321,0.0002319085,0.0001356716,0.0001037932,0.0003156126,0.0001188519,0.0002913381,0.0003245286],"category_scores_gemma":[0.0001435744,0.0001046966,0.0001719074,0.00008350512,0.0001235036,0.0002688258,0.000255193,0.000356136,0.000229508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863172,"about_ca_system_score_gemma":0.0001644487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000143174,"about_ca_topic_score_gemma":0.000260206,"domain_scores_codex":[0.9998988,0.00002698891,0.000008263375,0.00001778168,0.00003006154,0.00001817838],"domain_scores_gemma":[0.9999526,0.000008115375,0.00001381057,0.000004868805,0.00001105241,0.000009486677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006674272,0.00001298175,0.0001184754,0.00008437843,0.000005101153,0.00003007676,0.000008171778,0.0002223508,0.994792,0.0003705306,0.0000614545,0.004227724],"study_design_scores_gemma":[0.00001374145,0.0002548522,0.0005069565,0.00001229527,0.00001508109,0.0001579736,0.00001360905,0.001288223,0.9891279,0.000156849,0.008447338,0.000005045366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9173713,0.02713185,0.05076443,0.0004294114,0.000232279,0.0001524605,0.0006613798,0.0002157292,0.003041215],"genre_scores_gemma":[0.9813529,0.005676328,0.01086908,0.00007831035,0.00003578938,0.00005795058,0.000395811,0.00002088175,0.001512821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003245286,"threshold_uncertainty_score":0.001351893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00954530432669644,"score_gpt":0.2608252103659267,"score_spread":0.2512799060392302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}