{"id":"W4411866579","doi":"10.1021/acsnano.5c08831","title":"Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Adjuvant; Immune system; Dendritic cell; Immunology; Germinal center; Antigen; Biology; Antigen-presenting cell; Follicular dendritic cells; T cell; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001825563,0.0003447468,0.0002943462,0.00009128463,0.0001919764,0.0000655049,0.000512981,0.0003531806,0.00001232749],"category_scores_gemma":[0.0002913379,0.0003507951,0.0002224661,0.0001713805,0.00008087135,0.00001160833,0.0002413666,0.000141023,0.00002663001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002851308,"about_ca_system_score_gemma":0.0001505647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004555628,"about_ca_topic_score_gemma":0.0000165858,"domain_scores_codex":[0.998135,0.00008038255,0.0004231896,0.0006732097,0.0001661073,0.0005220865],"domain_scores_gemma":[0.9986721,0.00004827104,0.0001784533,0.0007666515,0.0002055039,0.0001289784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002526454,0.0002331242,0.003277829,0.0002433623,0.0000773885,0.0000252816,0.00002874011,0.00003582707,0.9793691,0.0001741061,0.0147099,0.001572702],"study_design_scores_gemma":[0.0018632,0.000102004,0.003574861,0.00008796505,0.0001189384,0.000009255732,0.0002082806,0.00005700501,0.9478844,0.0004997394,0.04522671,0.0003675824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700154,0.02576117,0.002208685,0.0003995683,0.0004543231,0.0006379784,0.000116217,0.00006056292,0.0003460658],"genre_scores_gemma":[0.9922358,0.000145712,0.00273637,0.001200736,0.0002737394,0.000130367,0.0001786999,0.00006299181,0.003035612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03148463,"threshold_uncertainty_score":0.9998944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00954530432669644,"score_gpt":0.2608252103659267,"score_spread":0.2512799060392302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}