{"id":"W4411885215","doi":"10.3899/jrheum.2025-0314.pod10","title":"Metabolic Stress Remodeling: Insights into the Role(s) of FOXO1 in Promoting Cancer-Like Changes in Systemic Sclerosis (SSc)","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"FOXO1; SOD2; Cancer research; Transcription factor; Mitochondrial ROS; Reactive oxygen species; Oxidative stress; Medicine; Biology; Superoxide dismutase; Cell biology; Immunology; Internal medicine; Signal transduction; Protein kinase B; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263645,0.000696025,0.0005009696,0.000640915,0.0003546236,0.000658913,0.0004090216,0.0008524132,0.009052415],"category_scores_gemma":[0.0001705684,0.0001517834,0.0005853812,0.0004419264,0.0004135382,0.0008972727,0.0005337144,0.001153856,0.0009310592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004443048,"about_ca_system_score_gemma":0.0004578424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005620203,"about_ca_topic_score_gemma":0.001012986,"domain_scores_codex":[0.9998901,0.00001323608,0.000004893077,0.00003514184,0.00002895407,0.00002763523],"domain_scores_gemma":[0.9999217,0.00000808432,0.00002527681,0.000004533915,0.00001524542,0.00002513772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386394,0.0004513932,0.006359949,0.01574439,0.0003876163,0.001649961,0.0005918509,0.00468195,0.5056872,0.03361026,0.03268388,0.3967651],"study_design_scores_gemma":[0.0003268582,0.002843191,0.05749134,0.002781216,0.0008233805,0.003736066,0.001429959,0.0110432,0.2118418,0.05538695,0.6520385,0.0002575308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1704919,0.7088052,0.04293619,0.03115672,0.004226862,0.000301318,0.007816355,0.001318123,0.03294734],"genre_scores_gemma":[0.5951244,0.3703294,0.01155614,0.003190247,0.001494913,0.0001785062,0.002639433,0.00007965921,0.01540735],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009052415,"threshold_uncertainty_score":0.03028339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746725689650967,"score_gpt":0.2645624576480069,"score_spread":0.2470952007514972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}