{"id":"W4411886845","doi":"10.1038/s41467-025-60753-x","title":"Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Université Laval; University of Victoria","funders":"National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; U.S. Department of Health and Human Services","keywords":"Microglia; In vivo; Cyclooxygenase; Vasodilation; Pathology; Intravital microscopy; Biology; Inflammation; Cell type; Cell biology; Neuroscience; Medicine; Chemistry; Cell; Endocrinology; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630035,0.0006493095,0.0004701078,0.001009864,0.0003534519,0.0005772912,0.0003947092,0.0005444942,0.001414698],"category_scores_gemma":[0.0002018875,0.0003875502,0.0004261378,0.0002290086,0.00076745,0.0004138847,0.0002908608,0.001230956,0.0003367574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007057802,"about_ca_system_score_gemma":0.0003737807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175825,"about_ca_topic_score_gemma":0.0031249,"domain_scores_codex":[0.9996476,0.00003987183,0.00002233267,0.00009687298,0.00008871745,0.0001047138],"domain_scores_gemma":[0.9995467,0.00005586793,0.0001906234,0.00004404739,0.00003212199,0.0001305684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000412822,0.0001162233,0.0002517678,0.00002562647,0.000008829924,0.00005422915,0.00004253796,0.0000680315,0.9976324,0.0001373543,0.00006668283,0.001183591],"study_design_scores_gemma":[0.00006656665,0.0009153488,0.008490507,0.00001824379,0.00005280968,0.0002356269,0.00007417843,0.001205162,0.9873604,0.0002014595,0.001365782,0.00001388255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926071,0.001269507,0.003829829,0.0002538702,0.00004479503,0.00005310666,0.0006471684,0.0002347773,0.001059818],"genre_scores_gemma":[0.9877145,0.001502579,0.004079094,0.0001440392,0.00002924081,0.0001686947,0.0007589788,0.0001220596,0.005480749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414698,"threshold_uncertainty_score":0.005120814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011755488544699,"score_gpt":0.3061938402094982,"score_spread":0.2860762853240513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}