{"id":"W4411886852","doi":"10.1038/s41467-025-60806-1","title":"Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal","funders":"National Institutes of Health; Cure Alzheimer's Fund; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Global Brain Health Institute; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Conselho Nacional de Desenvolvimento Científico e Tecnológico; HORIZON EUROPE Framework Programme; Alzheimer's Society; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Drug Discovery Foundation; Canadian Institutes of Health Research; Weston Brain Institute","keywords":"Disease; Neuroscience; Alzheimer's disease; Medicine; Reactivity (psychology); Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003603376,0.0003587055,0.0002365836,0.000953718,0.0003090547,0.0004022674,0.0001883866,0.0002731547,0.0006350889],"category_scores_gemma":[0.0008629872,0.0001482255,0.0001815936,0.0004376053,0.0002387629,0.0002241019,0.0003934516,0.0003101986,0.0001612825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699973,"about_ca_system_score_gemma":0.000110275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734461,"about_ca_topic_score_gemma":0.002465273,"domain_scores_codex":[0.9998648,0.00002303347,0.00002232934,0.00003271844,0.00003342496,0.00002379486],"domain_scores_gemma":[0.9994743,0.00003672486,0.0002779422,0.00003868678,0.0000912323,0.00008108203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001192632,0.000100582,0.9669008,0.00005232698,0.0001455007,0.0006834219,0.0003873942,0.00007934075,0.02075072,0.00006069794,0.0001651944,0.00948134],"study_design_scores_gemma":[0.000002352738,0.00013923,0.9978876,0.000005351506,0.00002310278,0.0007634239,0.00009662268,0.00004603225,0.0008964377,0.0000510947,0.00008674196,0.00000202803],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990864,0.0004526707,0.00005571177,0.00001180455,0.000003298398,0.000003053098,0.00004889352,0.000004229249,0.0003340045],"genre_scores_gemma":[0.9993333,0.0002196577,0.0001119545,0.00001646327,0.00000593496,0.000003395049,0.00009656006,0.000001514933,0.0002112139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734461,"threshold_uncertainty_score":0.003448665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261604870498911,"score_gpt":0.3580229008449947,"score_spread":0.3318624137951036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}