{"id":"W4411891040","doi":"10.3390/ijms26136352","title":"Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review","year":2025,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Liquid biopsy; Extracellular vesicles; Biopsy; Biomarker; Cancer biomarkers; Cancer; Cancer detection; Medicine; Pathology; Nanotechnology; Biology; Internal medicine; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006235838,0.000968005,0.001188341,0.002286408,0.0002317439,0.0008854146,0.0008070375,0.001015291,0.003027936],"category_scores_gemma":[0.0006998145,0.0004245543,0.000633698,0.001751678,0.0003374826,0.001364906,0.0006380262,0.001111694,0.001786121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004941982,"about_ca_system_score_gemma":0.00104225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008666116,"about_ca_topic_score_gemma":0.001143181,"domain_scores_codex":[0.9998287,0.00002792981,0.00002455406,0.00003305166,0.00006580201,0.00001997526],"domain_scores_gemma":[0.9996649,0.0001695672,0.00004745281,0.000008305388,0.0000847582,0.00002504141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006417292,0.0000819632,0.0001105565,0.02959423,0.00008812415,0.000162242,0.00006251311,0.000665296,0.004446841,0.004475041,0.02762958,0.9326196],"study_design_scores_gemma":[0.00001389342,0.0001333428,0.0004767821,0.003274914,0.00009962104,0.000740492,0.00004280653,0.0002511129,0.001651637,0.001374301,0.9919124,0.00002875471],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001526158,0.9981062,0.000383071,0.0001717806,0.0002520415,0.00001037044,0.00002023026,0.00001308889,0.0008905079],"genre_scores_gemma":[0.0007230853,0.9978446,0.0004504228,0.0001244405,0.0001441443,0.00001659971,0.00003314623,0.000002818098,0.0006607206],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003027936,"threshold_uncertainty_score":0.01012951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763601854858532,"score_gpt":0.320841470294646,"score_spread":0.3032054517460607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}