{"id":"W4411894640","doi":"10.1186/s13072-025-00602-9","title":"Detecting Protein-DNA binding in single molecules using antibody guided methylation","year":2025,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health; National Human Genome Research Institute; Tel Aviv University; National Institute of Diabetes and Digestive and Kidney Diseases; Israel Science Foundation","keywords":"Biology; DNA methylation; DNA; Human genetics; Computational biology; Genetics; Methylation; Antibody; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004690925,0.0004133904,0.000420728,0.0003521905,0.0001982812,0.0003710517,0.0004953296,0.0006769619,0.001322995],"category_scores_gemma":[0.0004652022,0.0003305735,0.0002476164,0.0002710693,0.0003850257,0.0003029596,0.0003967724,0.0008723247,0.0008615543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872433,"about_ca_system_score_gemma":0.0001812924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000485376,"about_ca_topic_score_gemma":0.001250708,"domain_scores_codex":[0.9996742,0.00004053109,0.00001469157,0.0001609,0.00007235639,0.00003739594],"domain_scores_gemma":[0.9995963,0.0001950797,0.00007433555,0.00005150448,0.00004555674,0.00003724639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001272085,0.000005562174,0.0001074243,0.00002728316,0.00000538035,0.000008627459,0.000009172565,0.00004905805,0.998664,0.00006543229,0.00001738383,0.001027979],"study_design_scores_gemma":[0.000003650345,0.00006504524,0.001218327,0.000002182504,0.000009415562,0.00004714071,0.000007440123,0.001777004,0.9957046,0.000091886,0.001068141,0.000005215312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7277514,0.001989119,0.2646969,0.0001979314,0.00008767036,0.0001789142,0.001024747,0.0009060234,0.00316728],"genre_scores_gemma":[0.8307819,0.001766195,0.1601339,0.0002048446,0.00003355196,0.0003580605,0.001030981,0.0001201026,0.005570505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322995,"threshold_uncertainty_score":0.004425824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605869902327995,"score_gpt":0.3227351582294808,"score_spread":0.2966764592062008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}