{"id":"W4411919169","doi":"10.1016/j.jbc.2025.110437","title":"Prediction of KIR3DL1 and human leukocyte antigen binding","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Biomedical Advanced Research and Development Authority; Victorian Cancer Agency; U.S. Navy; U.S. Public Health Service; Office of Naval Research; Health Resources and Services Administration; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Human leukocyte antigen; Computational biology; Sequence motif; Motif (music); HLA-B Antigens; Biology; Genetics; Antigen; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001460493,0.0006714301,0.0008852636,0.0007887704,0.0002024763,0.0007993291,0.0005599339,0.0009466683,0.001114133],"category_scores_gemma":[0.002573989,0.0002335592,0.0005928902,0.000448897,0.0001993226,0.0003953315,0.0003147712,0.0006998185,0.0004826031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000785517,"about_ca_system_score_gemma":0.000791355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005607677,"about_ca_topic_score_gemma":0.00416227,"domain_scores_codex":[0.9995716,0.0001675101,0.00002460498,0.00009192278,0.00007048118,0.00007392129],"domain_scores_gemma":[0.9990824,0.0006186077,0.00009167053,0.00004040817,0.00009705589,0.00006972523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006521668,0.0003120473,0.055158,0.00009175295,0.0001679828,0.0001777238,0.00004024776,0.8731032,0.01701892,0.0007669452,0.001259705,0.05125137],"study_design_scores_gemma":[0.000004489322,0.00002462399,0.001808486,0.000002498522,0.000004143479,0.00001560754,0.000005800214,0.9966331,0.001128999,0.0003131512,0.00005571199,0.000003463261],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298422,0.0005244879,0.06665463,0.0002689438,0.00002142914,0.00004347078,0.0006617651,0.0005194471,0.001463741],"genre_scores_gemma":[0.9893778,0.00007008903,0.009517902,0.0000596887,0.000006130552,0.00002219887,0.0004430705,0.00001504723,0.0004880227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005607677,"threshold_uncertainty_score":0.01115006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556529306198973,"score_gpt":0.255170516995911,"score_spread":0.2296052239339213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}