{"id":"W4411924783","doi":"10.1038/s41467-025-60726-0","title":"Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Impact; McMaster University","funders":"Canadian Institutes of Health Research; Government of Ontario; Canada Research Chairs; Government of Canada; National Sanitarium Association; McMaster University","keywords":"Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Immunity; Open label; Clinical trial; Virology; Immunology; Mucosal immunity; Immune system; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001801723,0.0002486337,0.0005263032,0.000283419,0.001341403,0.0001001291,0.002472493,0.001170986,0.0002128919],"category_scores_gemma":[0.003200306,0.0002456529,0.0001136833,0.0007499166,0.0002157176,0.0005492307,0.0009972701,0.002196325,0.00001906289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694609,"about_ca_system_score_gemma":0.000869541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004767912,"about_ca_topic_score_gemma":0.00104734,"domain_scores_codex":[0.994948,0.003195385,0.001133912,0.0003936103,0.00005782377,0.0002713257],"domain_scores_gemma":[0.9951709,0.001150157,0.0005209168,0.002630334,0.0004597252,0.00006796156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01777742,0.0290158,0.0005257661,0.00003822366,0.0008332742,0.000001002217,0.0006056434,0.000004688544,0.7737669,0.01413233,0.1454092,0.01788975],"study_design_scores_gemma":[0.5059758,0.005262744,0.002316793,0.0001085708,0.00118901,0.00008159359,0.001506162,0.004888568,0.04989817,0.0002451263,0.4272808,0.00124667],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523697,0.0279366,0.002771131,0.01019765,0.002530617,0.00314215,0.0004441995,0.0001880603,0.0004198726],"genre_scores_gemma":[0.9878279,0.002054324,0.001843592,0.001160711,0.00004393888,0.0003011599,0.005391121,0.00002239147,0.001354842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7238688,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1695245434321999,"score_gpt":0.4761235213164646,"score_spread":0.3065989778842647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}