{"id":"W4411926136","doi":"10.1177/03331024251314460","title":"Genetic characterization of the endocannabinoid system and psychiatric features in patients with migraine and medication overuse headache","year":2025,"lang":"en","type":"article","venue":"Cephalalgia","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fatty acid amide hydrolase; Endocannabinoid system; Medicine; Migraine; Hamilton Anxiety Rating Scale; TRPV1; Anandamide; Internal medicine; Cannabinoid receptor; Pharmacology; Receptor; Anxiety; Psychiatry; Transient receptor potential channel","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109363,0.00009794164,0.0001812264,0.0001742778,0.00005250732,0.00001352779,0.00006117457,0.00006367927,0.000005177238],"category_scores_gemma":[0.00003808831,0.00006067522,0.0000228855,0.0004375272,0.000113154,0.00003494905,0.00004437387,0.0001356642,2.219576e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000562172,"about_ca_system_score_gemma":0.0001295813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001027202,"about_ca_topic_score_gemma":0.00003115703,"domain_scores_codex":[0.9991555,0.00005445924,0.0001961205,0.000196837,0.0002566148,0.0001404869],"domain_scores_gemma":[0.9995211,0.000005788794,0.0000773549,0.0002285809,0.0001058798,0.00006133274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002232044,0.0001078896,0.987351,0.0008330311,0.0000243922,0.00000134266,0.0002056638,4.33004e-7,0.004847898,0.0002970312,0.00174281,0.00436528],"study_design_scores_gemma":[0.002066076,0.0001397291,0.9955714,0.0002325268,0.00005078201,0.00000805352,0.00006524013,0.00005164551,0.0007806749,0.00000778643,0.0009754873,0.00005055736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946888,0.0007707938,0.00001658429,0.003501099,0.00008405311,0.0006984136,0.0000126683,0.00001056899,0.000217008],"genre_scores_gemma":[0.9980569,0.00006339044,0.00003137179,0.0001339257,0.00002357244,0.00003850851,0.00002012947,0.000009327689,0.001622872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008220416,"threshold_uncertainty_score":0.2474264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002793258284116804,"score_gpt":0.2212745504710032,"score_spread":0.2184812921868864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}