{"id":"W4411926667","doi":"10.1186/s12866-025-04126-w","title":"Inferred bi-directional interactions between vaginal microbiota, metabolome and persistent HPV infection accompanied by high-grade cervical intraepithelial neoplasia","year":2025,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Key Research and Development Program of China","keywords":"Metabolome; Biology; Cervical intraepithelial neoplasia; Parasitology; Internal medicine; Cervical cancer; Metabolomics; Bioinformatics; Genetics; Zoology; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040556,0.000362565,0.0003822667,0.0007657449,0.0003852324,0.000687996,0.0001634717,0.0002648053,0.001042351],"category_scores_gemma":[0.0007770294,0.0001581188,0.0004665155,0.001011208,0.0001736743,0.0002660879,0.0005275244,0.0002360359,0.0001460116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002450501,"about_ca_system_score_gemma":0.0004116885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00409637,"about_ca_topic_score_gemma":0.006857202,"domain_scores_codex":[0.9997595,0.00004276054,0.00002194245,0.00008363537,0.00003789255,0.00005424561],"domain_scores_gemma":[0.9996299,0.00006210684,0.0001508706,0.00004302836,0.00006134863,0.00005274092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004300053,0.00002691138,0.9787218,0.0001104884,0.0003066895,0.0001246013,0.0001209971,0.0001295688,0.01350143,0.00004714751,0.0001358849,0.006344442],"study_design_scores_gemma":[0.000003089484,0.00006652479,0.9977798,0.00001082903,0.0001424404,0.0001840396,0.0001555182,0.0004231129,0.0008561485,0.00007138457,0.0003025276,0.000004724723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962309,0.001397521,0.000501038,0.00006863396,0.00001053341,0.00001791992,0.001288726,0.00001117326,0.0004734502],"genre_scores_gemma":[0.9983665,0.0002755855,0.0003677409,0.00003534212,0.000009183818,0.00001184569,0.0007409242,0.000003560849,0.0001893548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00409637,"threshold_uncertainty_score":0.008145034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971859883467538,"score_gpt":0.2925892875013417,"score_spread":0.2728706886666664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}