{"id":"W4411928258","doi":"10.1016/j.jep.2025.120221","title":"Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Ministry of SMEs and Startups; Natural Science Foundation of Fujian Province; National Natural Science Foundation of China","keywords":"Tauopathy; Neuroinflammation; Oxidative stress; Morris water navigation task; MAPK/ERK pathway; Neuroprotection; Pharmacology; Tau protein; GSK3B; Neuroscience; Biology; Medicine; Neurodegeneration; Pathology; Protein kinase B; Alzheimer's disease; Phosphorylation; Cell biology; Internal medicine; Inflammation; Hippocampus; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278218,0.0006129569,0.0005398404,0.0004688281,0.0001963172,0.0002295735,0.0001849383,0.0003082954,0.001121869],"category_scores_gemma":[0.00007770598,0.0001442175,0.0004346792,0.0002029744,0.0002820857,0.0003162777,0.000203381,0.0008706814,0.0001617591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298613,"about_ca_system_score_gemma":0.0002316387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002924351,"about_ca_topic_score_gemma":0.0005837632,"domain_scores_codex":[0.9999522,0.000006900182,0.00000643758,0.000009572684,0.00001186267,0.0000129226],"domain_scores_gemma":[0.999954,0.00000383561,0.00001425273,0.000003341623,0.000009283721,0.00001528182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001842099,0.0003671945,0.00061464,0.0005300627,0.00006197614,0.0001347901,0.00004483176,0.0001900393,0.9844802,0.0001247206,0.0002302423,0.0113793],"study_design_scores_gemma":[0.001476275,0.007667841,0.07271979,0.0002179437,0.0008291225,0.001161492,0.0003235288,0.005547234,0.8906337,0.001693175,0.01765814,0.00007183067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832981,0.01162299,0.002646829,0.0003061481,0.0000926055,0.00008980239,0.0005017969,0.0001721049,0.001269734],"genre_scores_gemma":[0.9850145,0.009586317,0.00286746,0.0001954251,0.0000458207,0.0001772642,0.0005317898,0.00002335922,0.001558041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121869,"threshold_uncertainty_score":0.003753066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112410442328183,"score_gpt":0.3625371527560524,"score_spread":0.3414130483327706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}