{"id":"W4411928345","doi":"10.1093/bjd/ljaf236","title":"Efficacy and safety of upadacitinib dose escalation and reduction in adults with moderate-to-severe atopic dermatitis: results of a randomized blinded treat-to-target multicentre phase IIIb/IV study (Flex Up)","year":2025,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; Probity Medical Research; SKiN Health; Queen's University","funders":"AbbVie","keywords":"Eczema Area and Severity Index; Medicine; Atopic dermatitis; Clinical endpoint; Randomized controlled trial; Adverse effect; Internal medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003648921,0.0009737539,0.002275418,0.0003019946,0.0003583329,0.0007376724,0.000731072,0.001003862,0.002605038],"category_scores_gemma":[0.001826315,0.0004936307,0.001486596,0.0003242519,0.0007454547,0.0007786267,0.0003928115,0.002193979,0.0004152799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006730205,"about_ca_system_score_gemma":0.001119811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004264799,"about_ca_topic_score_gemma":0.001165183,"domain_scores_codex":[0.9987864,0.0007286782,0.00009604078,0.0001516286,0.0001209791,0.000116208],"domain_scores_gemma":[0.9987059,0.0002769786,0.0003887792,0.0001413056,0.0001068509,0.0003802403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9182354,0.01891583,0.003132805,0.0005168959,0.001279934,0.00004222716,0.00008325434,0.0004941106,0.009439741,0.00006822014,0.001182487,0.04660923],"study_design_scores_gemma":[0.7804409,0.2044245,0.01125566,0.00003310575,0.0008469196,0.00009687903,0.00002301107,0.000521265,0.001499124,0.00007733783,0.0007594335,0.00002195556],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929848,0.002612841,0.0004977131,0.0002385258,0.00008946749,0.002190627,0.0005863397,0.00006056497,0.0007390433],"genre_scores_gemma":[0.993629,0.001178686,0.001566803,0.0005028282,0.0001259564,0.001640638,0.0007246215,0.0000148289,0.0006167082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003648921,"threshold_uncertainty_score":0.0192976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009325407154275793,"score_gpt":0.289878256429685,"score_spread":0.2805528492754092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}