{"id":"W4411929975","doi":"10.3390/biom15070934","title":"Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Beijing Normal University","keywords":"Fisetin; Myricetin; DYRK1A; Flavonols; Luteolin; Apigenin; Kaempferol; Chrysin; Chemistry; IC50; Pharmacology; Isorhamnetin; Galangin; Biochemistry; Quercetin; Flavonoid; Kinase; Flavones; Drug discovery; Curcumin; Biology; In vitro; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002021769,0.0004370389,0.0006038717,0.0006935344,0.0001360891,0.0002872369,0.0002677875,0.0003256869,0.001183269],"category_scores_gemma":[0.0001311307,0.0001563223,0.0004306349,0.0003271358,0.0001114792,0.0002488059,0.0002488956,0.0004098467,0.0003711492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141308,"about_ca_system_score_gemma":0.0002252133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004997701,"about_ca_topic_score_gemma":0.001844701,"domain_scores_codex":[0.9999515,0.000006556699,0.00000372211,0.00001037914,0.00001746472,0.00001039881],"domain_scores_gemma":[0.9999677,0.000004834372,0.000007920143,0.000002347074,0.000009080522,0.000008242497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003218726,0.0002010708,0.000624116,0.00053731,0.00008670023,0.0004436231,0.00005721743,0.0008636159,0.9558716,0.0005064232,0.0007371171,0.03974925],"study_design_scores_gemma":[0.0009720408,0.00519762,0.01246683,0.000231569,0.0006083008,0.001953753,0.00009691023,0.005933237,0.9008897,0.0006795748,0.07088483,0.00008565611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9271534,0.04507812,0.01570905,0.0005918834,0.0001089557,0.000651042,0.001995342,0.0003423849,0.008369704],"genre_scores_gemma":[0.9486697,0.02251244,0.02095595,0.0005493217,0.00005062452,0.0002485899,0.002031541,0.00004207388,0.004939675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183269,"threshold_uncertainty_score":0.003958464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856195646832611,"score_gpt":0.2613336478504365,"score_spread":0.2527716913821104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}