{"id":"W4411929975","doi":"10.3390/biom15070934","title":"Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Beijing Normal University","keywords":"Fisetin; Myricetin; DYRK1A; Flavonols; Luteolin; Apigenin; Kaempferol; Chrysin; Chemistry; IC50; Pharmacology; Isorhamnetin; Galangin; Biochemistry; Quercetin; Flavonoid; Kinase; Flavones; Drug discovery; Curcumin; Biology; In vitro; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006622,0.0001864892,0.0001676053,0.0001088377,0.00008060517,0.00003597464,0.0002137706,0.0001392942,0.0000072782],"category_scores_gemma":[0.0002079253,0.0001763865,0.0001698065,0.000146025,0.0001412892,0.000009935413,0.0002394733,0.00009204492,0.00001148067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002559201,"about_ca_system_score_gemma":0.0001293911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003447256,"about_ca_topic_score_gemma":0.00004328134,"domain_scores_codex":[0.9989012,0.00003904603,0.000329197,0.0003685958,0.0001285399,0.0002334419],"domain_scores_gemma":[0.9993796,0.00001990226,0.0001257143,0.0003491203,0.00008083708,0.00004487863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074617,0.0001791811,0.0003117003,0.00004619285,0.0001145182,0.00000856452,0.00002237995,0.0000182791,0.9932954,0.0007689719,0.004250982,0.0008763735],"study_design_scores_gemma":[0.000324151,0.0001638276,0.0006605083,0.0001149043,0.00002960965,0.000008925312,0.0002009092,0.00002461199,0.9874553,0.0001152663,0.01072346,0.0001785401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863459,0.001938004,0.00687914,0.0005983763,0.0006075611,0.0003118395,0.0002231576,0.00002484597,0.003071145],"genre_scores_gemma":[0.9964294,0.0001022858,0.001604524,0.0002630998,0.0001368147,0.00003945174,0.0003247677,0.00002001376,0.001079679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01008343,"threshold_uncertainty_score":0.7192831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856195646832611,"score_gpt":0.2613336478504365,"score_spread":0.2527716913821104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}