{"id":"W4411932090","doi":"10.1016/j.stem.2025.06.006","title":"TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice","year":2025,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Intramural Research Program; National Cancer Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Eye Institute; National Institute on Aging; National Institutes of Health; National Institute of Mental Health and Neurosciences; Huffington Foundation; American Society of Hematology; Howard Hughes Medical Institute; Cancer Prevention and Research Institute of Texas; Ting Tsung and Wei Fong Chao Family Foundation; Edward P. Evans Foundation","keywords":"Biology; Phagocytosis; Myeloid cells; Infiltration (HVAC); Mutant; Myeloid; Disease; Microglia; Cancer research; Cell biology; Immunology; Inflammation; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085543,0.0003438439,0.0002765165,0.0004530188,0.0001468949,0.0003166678,0.0001970895,0.0003593657,0.001935232],"category_scores_gemma":[0.000101213,0.0001460017,0.0002321846,0.0001377727,0.0002940844,0.000233443,0.0002601964,0.0007997684,0.0004165535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137424,"about_ca_system_score_gemma":0.0002274709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000559748,"about_ca_topic_score_gemma":0.00165032,"domain_scores_codex":[0.9998401,0.00002405174,0.00001293751,0.0000345972,0.00004007104,0.00004813508],"domain_scores_gemma":[0.9998482,0.00001048698,0.00005002137,0.00001481079,0.00001295005,0.00006339446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003764534,0.0000784756,0.0002539086,0.00003385481,0.00001023819,0.00003819751,0.00002917871,0.00006497622,0.9963254,0.0001771247,0.0001162472,0.002495877],"study_design_scores_gemma":[0.0001074924,0.002215694,0.009101431,0.00003167683,0.00007324729,0.0003288174,0.00009846908,0.001138703,0.9797078,0.0002455447,0.006939096,0.00001209629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945908,0.0009083824,0.001916798,0.0001869713,0.00003993371,0.00003285804,0.0005777962,0.0001940817,0.001552401],"genre_scores_gemma":[0.991246,0.0007116472,0.00140577,0.0001421718,0.0000179492,0.00006263824,0.0005609993,0.00005223031,0.005800562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935232,"threshold_uncertainty_score":0.006474018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00817282172189912,"score_gpt":0.2407104718278414,"score_spread":0.2325376501059423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}