{"id":"W4411932276","doi":"10.1038/s41586-025-09219-0","title":"The mutagenic forces shaping the genomes of lung cancer in never smokers","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; World Health Organization","keywords":"Lung cancer; Genome; Biology; Genetics; Computational biology; Medicine; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169187,0.00006746839,0.00006706562,0.00001902561,0.00007779975,0.00001732231,0.0002364947,0.0002811718,0.000007611621],"category_scores_gemma":[0.00007192602,0.0000409018,0.00005664337,0.0001108316,0.00005931953,0.00000147274,0.00009708759,0.0003185291,1.593931e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002393234,"about_ca_system_score_gemma":0.0001356604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008878097,"about_ca_topic_score_gemma":0.001072919,"domain_scores_codex":[0.9995635,0.00001639387,0.0001076227,0.0001277351,0.00005636349,0.000128428],"domain_scores_gemma":[0.999633,0.0000563787,0.00004238331,0.0002136277,0.00004327934,0.0000113522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007413159,0.0001156028,0.2377624,0.0003344193,0.001253893,0.000009956177,0.00113697,0.0113036,0.418033,0.03369688,0.1836587,0.1119532],"study_design_scores_gemma":[0.0009079816,0.00004655901,0.09372604,0.00009232271,0.00008216937,0.000001527792,0.0004288858,0.001203604,0.0860955,0.0009462492,0.8162312,0.0002379511],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8246855,0.1687937,0.00003371005,0.003792691,0.0005633309,0.0002135975,0.00003920267,0.000002661186,0.001875673],"genre_scores_gemma":[0.9890764,0.008168509,0.00001537228,0.001884347,0.0001015779,0.00002256375,0.000007259827,0.000005980532,0.0007180041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6325725,"threshold_uncertainty_score":0.2168655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004430492176000491,"score_gpt":0.2770889646125205,"score_spread":0.27265847243652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}