{"id":"W4411932276","doi":"10.1038/s41586-025-09219-0","title":"The mutagenic forces shaping the genomes of lung cancer in never smokers","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; World Health Organization","keywords":"Lung cancer; Genome; Biology; Genetics; Computational biology; Medicine; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004495684,0.000111304,0.0001777822,0.0005650398,0.000492799,0.000646272,0.0002543319,0.0007629737,0.001748527],"category_scores_gemma":[0.001392176,0.0002407016,0.0001990519,0.0004235424,0.0005406667,0.0004390573,0.0004673211,0.0007347647,0.0001967851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003363703,"about_ca_system_score_gemma":0.0005195334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003795523,"about_ca_topic_score_gemma":0.006029935,"domain_scores_codex":[0.9996765,0.00008761869,0.00001300534,0.00006593847,0.00008620025,0.00007080834],"domain_scores_gemma":[0.999382,0.0002536134,0.0001267802,0.00004804635,0.00008652624,0.0001030278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001088706,0.0001175018,0.4981816,0.0002211093,0.0002184187,0.001065722,0.002460993,0.002249004,0.401884,0.02122985,0.002020548,0.06926253],"study_design_scores_gemma":[0.0000339432,0.0003683077,0.9192335,0.0001156293,0.0001811346,0.00180179,0.002610991,0.00235756,0.03398904,0.02015033,0.01910996,0.00004778813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881818,0.003671698,0.001963673,0.002587819,0.00005319596,0.00001012438,0.0005279943,0.0000278107,0.0029758],"genre_scores_gemma":[0.9954516,0.001756912,0.0005529273,0.0005777052,0.00004901095,0.000007091624,0.0002230698,0.00001495409,0.001366763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003795523,"threshold_uncertainty_score":0.007546902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004430492176000491,"score_gpt":0.2770889646125205,"score_spread":0.27265847243652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}