{"id":"W4411954234","doi":"10.1021/acschembio.5c00338","title":"Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Discovery Centre","funders":"Cancer Research UK; Wellcome Trust; Merck KGaA","keywords":"RNA polymerase II; Mediator; Biology; Kinase; Cyclin-dependent kinase 8; Chromatin; Cyclin-dependent kinase; Cell biology; Transcription factor; Gene expression; Cancer research; Signal transduction; Gene; Cell cycle; Biochemistry; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855908,0.0002968937,0.0002687405,0.0003118621,0.00009967745,0.0002660737,0.0002316831,0.0002302971,0.002123624],"category_scores_gemma":[0.0001585615,0.0001367476,0.000136735,0.0002537225,0.00009771941,0.0001908698,0.0001141102,0.0002339885,0.0003957711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003444546,"about_ca_system_score_gemma":0.0002298799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136352,"about_ca_topic_score_gemma":0.001908272,"domain_scores_codex":[0.9998921,0.00001219201,0.000009402432,0.00003014942,0.00003148737,0.00002462391],"domain_scores_gemma":[0.9999381,0.00001700148,0.00001233475,0.000006404148,0.00001389303,0.00001219509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340835,0.00001141222,0.000124219,0.0000415695,0.000004963254,0.00002038259,0.000003664989,0.00009171655,0.9975031,0.00004825688,0.00007899111,0.001937539],"study_design_scores_gemma":[0.00001681626,0.0001557067,0.001451161,0.000002092936,0.00001635417,0.000131797,0.000005499292,0.0007431206,0.9954728,0.00001637357,0.001984368,0.000003702098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711377,0.01123002,0.008314097,0.0002876977,0.00004842302,0.00009431141,0.002140159,0.0004944879,0.00625309],"genre_scores_gemma":[0.9802077,0.005213328,0.006889722,0.00009271935,0.00001064195,0.00008570583,0.002049668,0.0000843602,0.005366118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123624,"threshold_uncertainty_score":0.007104218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00701042131851761,"score_gpt":0.2787799358848442,"score_spread":0.2717695145663266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}