{"id":"W4411954234","doi":"10.1021/acschembio.5c00338","title":"Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Discovery Centre","funders":"Cancer Research UK; Wellcome Trust; Merck KGaA","keywords":"RNA polymerase II; Mediator; Biology; Kinase; Cyclin-dependent kinase 8; Chromatin; Cyclin-dependent kinase; Cell biology; Transcription factor; Gene expression; Cancer research; Signal transduction; Gene; Cell cycle; Biochemistry; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021741,0.0001323239,0.0003263996,0.00009751462,0.00001961494,0.000003583938,0.00004972848,0.0003505978,0.00002327795],"category_scores_gemma":[0.0004031211,0.0001202857,0.00003858406,0.0003277317,0.0001920741,0.00002286907,0.0001025223,0.0004259194,0.000003544064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637092,"about_ca_system_score_gemma":0.0002500161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002483148,"about_ca_topic_score_gemma":0.0001776676,"domain_scores_codex":[0.9991255,0.00005111012,0.0001389412,0.0003662253,0.00005403515,0.000264204],"domain_scores_gemma":[0.9995759,0.0001458329,0.00003521708,0.0001113769,0.00004052016,0.00009116538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000484824,0.0001165904,0.04272635,0.00003716819,0.00003979768,0.00001531927,0.00003741532,1.850161e-7,0.941353,0.00007628053,0.0003825919,0.01473046],"study_design_scores_gemma":[0.001753168,0.00009328416,0.01705582,0.00005199203,0.0000367254,0.00001080512,0.000004538585,0.00006142595,0.9788797,0.0002105056,0.001741397,0.0001006222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962301,0.0009176597,0.00003027265,0.001771446,0.0002234063,0.0002750528,0.00002071582,0.0000458254,0.0004855068],"genre_scores_gemma":[0.9991476,0.0001614845,0.00006220663,0.0003854295,0.0001015654,0.00009132575,0.00001643084,0.00000935548,0.00002462854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0375267,"threshold_uncertainty_score":0.4905108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00701042131851761,"score_gpt":0.2787799358848442,"score_spread":0.2717695145663266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}