{"id":"W4411957172","doi":"10.1016/j.jcoa.2025.100236","title":"Metabolite patterns of the carbonic anhydrase inhibitors brinzolamide and dorzolamide: potential markers for the route of application","year":2025,"lang":"en","type":"article","venue":"Journal of Chromatography Open","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Manfred Donike Institut für Dopinganalytik; Bundesministerium des Innern, für Bau und Heimat; World Anti-Doping Agency","keywords":"Dorzolamide; Carbonic anhydrase; Metabolite; Chemistry; Pharmacology; Biochemistry; Enzyme; Biology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139273,0.0003796085,0.0002533928,0.0004091641,0.000100319,0.0004114253,0.0001576709,0.0005299496,0.000583398],"category_scores_gemma":[0.0003963339,0.0001967403,0.0003050257,0.0001939378,0.0002396183,0.0002344521,0.0001228989,0.0004267842,0.0002097579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476632,"about_ca_system_score_gemma":0.0003032245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404895,"about_ca_topic_score_gemma":0.001712059,"domain_scores_codex":[0.9997172,0.0000436222,0.00001417411,0.00008699784,0.0001006551,0.00003730044],"domain_scores_gemma":[0.9996756,0.00004732926,0.0001448361,0.00001840536,0.00007912338,0.00003476819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005334128,0.00003456457,0.005878348,0.00006519515,0.00003054674,0.00009024627,0.00005082389,0.00004355102,0.9874537,0.00003759478,0.00003831514,0.005743628],"study_design_scores_gemma":[0.00002524226,0.003015658,0.1183211,0.00002774555,0.0001231309,0.0009309069,0.0001493097,0.001219038,0.8736544,0.00008046284,0.002419565,0.00003349859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873882,0.00416432,0.006053831,0.00009073952,0.00003681487,0.00008927456,0.0007045069,0.00005343277,0.001418907],"genre_scores_gemma":[0.9891237,0.001835611,0.006046454,0.0001411585,0.00001884652,0.00007402727,0.0005617571,0.00002408798,0.002174329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404895,"threshold_uncertainty_score":0.002793431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003673023088428789,"score_gpt":0.2402128242257197,"score_spread":0.2365398011372909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}