{"id":"W4411958948","doi":"10.1096/fj.202500010rr","title":"<scp>NTPDase8</scp> Protects Against Liver Ischemia–Reperfusion Injury in Mice","year":2025,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Liver injury; Reperfusion injury; Purinergic receptor; Bone marrow; Hepatocyte; Purinergic signalling; Ischemia; Medicine; Pharmacology; Immunology; Biology; Endocrinology; Chemistry; Internal medicine; Agonist; Receptor; Adenosine; Biochemistry; Adenosine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003733442,0.001155632,0.0009057986,0.0008276114,0.0003391716,0.0005346105,0.0005332774,0.001231018,0.004354153],"category_scores_gemma":[0.0001874007,0.0004193972,0.0006076153,0.0003244476,0.0008123407,0.0006055067,0.0003137382,0.002338465,0.001693091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005556443,"about_ca_system_score_gemma":0.0004841992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085145,"about_ca_topic_score_gemma":0.001698697,"domain_scores_codex":[0.9995651,0.00006824832,0.00005664663,0.0000994958,0.00009948782,0.0001110601],"domain_scores_gemma":[0.9996127,0.00003066614,0.0001227886,0.00005941018,0.00003993151,0.0001345779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001230208,0.0002755964,0.0001574841,0.00006573508,0.00002312204,0.0001268564,0.00001927589,0.0001139644,0.9954608,0.0001915957,0.0003206446,0.002014566],"study_design_scores_gemma":[0.0004017594,0.003463761,0.004465471,0.00003947437,0.00005970658,0.0008439993,0.00008088028,0.001695577,0.9808961,0.0001978677,0.007832677,0.00002272082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832376,0.002176507,0.004236077,0.001024618,0.0002811822,0.0002099284,0.003640745,0.0008917683,0.004301585],"genre_scores_gemma":[0.9696452,0.001595644,0.005194164,0.0006633839,0.00008744304,0.0004772095,0.004168143,0.0002746642,0.01789424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004354153,"threshold_uncertainty_score":0.01456606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007073666699439304,"score_gpt":0.234134900163778,"score_spread":0.2270612334643387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}