{"id":"W4411964743","doi":"10.1016/j.jhepr.2025.101508","title":"Genetic risk score correlates with immune profile and risk of HCC and cirrhosis development in Hispanics with MASLD","year":2025,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Horizon 2020 Framework Programme; National Cancer Institute; Erasmus Universitair Medisch Centrum Rotterdam; Universidad San Francisco de Quito; Pontificia Universidad Católica de Chile; Fondo Nacional de Desarrollo Científico y Tecnológico; Universidad de Navarra; University of Toronto; Euskal Herriko Unibertsitatea; Stichting voor Lever- en Maag-Darm Onderzoek; University of Minnesota","keywords":"Cirrhosis; Internal medicine; Immune system; Medicine; Oncology; Hepatocellular carcinoma; Framingham Risk Score; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187271,0.0001481206,0.000338296,0.0001039921,0.00005589226,0.00001140271,0.00001775435,0.00004835402,0.00002080081],"category_scores_gemma":[0.00003661535,0.00009604367,0.00002198825,0.0001610489,0.00007024952,0.00003255752,0.00004186085,0.00009764778,4.974241e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006352355,"about_ca_system_score_gemma":0.0002340212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960286,"about_ca_topic_score_gemma":0.0002102568,"domain_scores_codex":[0.9990238,0.00002224443,0.0003468649,0.000309128,0.0001590654,0.0001388845],"domain_scores_gemma":[0.9992791,0.00004916669,0.0002647224,0.0002528559,0.0000731703,0.0000809733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00017975,0.0003306119,0.9872061,0.0001849807,0.0004606251,0.0007720619,0.0003832585,0.00001068687,0.00001979862,0.000008999646,0.00005754942,0.01038556],"study_design_scores_gemma":[0.001406504,0.0003067239,0.9938508,0.0008592735,0.000871052,0.0001372284,0.0001185183,0.00006816169,0.002053984,0.00003896627,0.0001876216,0.0001011627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917898,0.007006438,0.00001752125,0.00005066087,0.0000307272,0.0007179818,0.000007223803,0.00001515204,0.0003644661],"genre_scores_gemma":[0.9950032,0.002104837,0.002506634,0.00001767594,0.000004820763,0.0001389019,0.00001650353,0.00001274942,0.0001947105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028439,"threshold_uncertainty_score":0.3916547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004282798868604924,"score_gpt":0.2026324780206434,"score_spread":0.1983496791520384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}