{"id":"W4411974173","doi":"10.3390/curroncol32070384","title":"Real-World Retrospective Study of Clinical and Economic Outcomes Among Patients with Locally Advanced or Metastatic Urothelial Carcinoma Treated with First-Line Systemic Anti-Cancer Therapies in the United States: Results from the IMPACT UC-III Study","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"EMD Serono; Merck KGaA; Johns Hopkins University","keywords":"Medicine; Metastatic Urothelial Carcinoma; Urothelial carcinoma; Urothelial cancer; Oncology; Systemic therapy; Cancer; Internal medicine; Retrospective cohort study; Bladder cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001389155,0.0004331174,0.000661437,0.001237169,0.0004877399,0.001130867,0.0005716076,0.000574376,0.001131312],"category_scores_gemma":[0.003996886,0.0004899073,0.0008255324,0.003141036,0.0003148417,0.0008457046,0.0009827225,0.0007394898,0.0002773289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001065269,"about_ca_system_score_gemma":0.0007617144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01729885,"about_ca_topic_score_gemma":0.01535194,"domain_scores_codex":[0.9987006,0.0003823014,0.0002640695,0.0002598669,0.0001977753,0.0001954108],"domain_scores_gemma":[0.9952663,0.0006099378,0.002904893,0.0003203274,0.0003931533,0.0005053783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001129599,0.00003639576,0.9991055,0.00001118,0.00008307928,0.0000486031,0.000026829,0.00004486534,0.0000184387,0.00001096984,0.0002106123,0.0002905407],"study_design_scores_gemma":[0.00002712074,0.00008979817,0.998572,0.00001616272,0.00005855629,0.0002584714,0.000249932,0.000349238,0.00002375367,0.00001504527,0.0003324369,0.00000745908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945147,0.0003272601,0.00006343798,0.00005943832,0.000005585703,0.00002827902,0.00473951,0.000002977343,0.0002589186],"genre_scores_gemma":[0.9937611,0.0002109809,0.0001080097,0.00007880986,0.0000133698,0.00004854154,0.005705514,0.000003423275,0.00007015806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01729885,"threshold_uncertainty_score":0.03439629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07389743370804301,"score_gpt":0.4253334390539458,"score_spread":0.3514360053459028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}