{"id":"W4411981916","doi":"10.1172/jci.insight.191951","title":"MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institutes of Health; Seqirus; Biomedical Advanced Research and Development Authority; China Scholarship Council; National Institute for Health and Care Research; Moderna; Parker Institute for Cancer Immunotherapy; Biomedical Laboratory Research and Development, VA Office of Research and Development; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Pfizer; Bill and Melinda Gates Foundation; U.S. Department of Veterans Affairs; Office of Research and Development; Sanofi; Cancer Research Institute; National Science Foundation","keywords":"Mechanical ventilation; Medicine; Lung; Coronavirus disease 2019 (COVID-19); Polymorphism (computer science); Internal medicine; Cardiology; Intensive care medicine; Biology; Gene; Genetics; Genotype; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195179,0.0001284546,0.0002840059,0.000208071,0.00008295131,0.00001230565,0.00005845413,0.0001337975,0.00006695926],"category_scores_gemma":[0.00002973448,0.000109408,0.00008557378,0.0001438365,0.00002513057,0.0001414353,0.0000548646,0.0001676413,0.000004233462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000368191,"about_ca_system_score_gemma":0.00008618205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000181396,"about_ca_topic_score_gemma":0.000001852321,"domain_scores_codex":[0.9990935,0.00003332411,0.0003067268,0.0002366586,0.0001669802,0.0001628625],"domain_scores_gemma":[0.9995093,0.00001691564,0.0001202027,0.0002163527,0.00005223687,0.00008493267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006186829,0.00009456397,0.01063535,0.00009696952,0.0002389917,0.00004777702,0.0002424169,2.176288e-7,0.9795439,0.00350827,0.0002424979,0.004730367],"study_design_scores_gemma":[0.001115042,0.0002961124,0.04237195,0.0001604655,0.0004945868,0.00001645271,0.0000525154,0.0001349882,0.9513709,0.0009690826,0.002907548,0.0001103342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966156,0.000706749,0.000485921,0.0001219348,0.0003323426,0.0002546611,0.00001221514,0.00004357087,0.001427015],"genre_scores_gemma":[0.9971138,0.0001638576,0.0007862192,0.0001346752,0.00009563495,0.00001176546,0.00001326894,0.00001350706,0.001667237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0317366,"threshold_uncertainty_score":0.4461527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008902314845956076,"score_gpt":0.2760641169310254,"score_spread":0.2671618020850694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}