{"id":"W4411981916","doi":"10.1172/jci.insight.191951","title":"MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institutes of Health; Seqirus; Biomedical Advanced Research and Development Authority; China Scholarship Council; National Institute for Health and Care Research; Moderna; Parker Institute for Cancer Immunotherapy; Biomedical Laboratory Research and Development, VA Office of Research and Development; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Pfizer; Bill and Melinda Gates Foundation; U.S. Department of Veterans Affairs; Office of Research and Development; Sanofi; Cancer Research Institute; National Science Foundation","keywords":"Mechanical ventilation; Medicine; Lung; Coronavirus disease 2019 (COVID-19); Polymorphism (computer science); Internal medicine; Cardiology; Intensive care medicine; Biology; Gene; Genetics; Genotype; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205594,0.0002682137,0.0003072503,0.0001813572,0.0001627333,0.0002473691,0.0001712004,0.000372561,0.002020409],"category_scores_gemma":[0.0005752328,0.0001154375,0.0002527801,0.0001794862,0.0001123867,0.0001097848,0.0001877641,0.0003649497,0.0002317098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300663,"about_ca_system_score_gemma":0.0001066641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293,"about_ca_topic_score_gemma":0.001288083,"domain_scores_codex":[0.9998442,0.00005103982,0.000009804449,0.00002821007,0.00002852649,0.00003832426],"domain_scores_gemma":[0.9997345,0.00003828754,0.00008190685,0.00002216106,0.00001480747,0.0001083941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02226117,0.001160593,0.8926041,0.00008747619,0.0005601528,0.0004858822,0.0001242891,0.0003854632,0.04611211,0.00009105102,0.001120009,0.03500764],"study_design_scores_gemma":[0.0001463201,0.001799018,0.9944341,0.00001041107,0.0001101653,0.0004344221,0.00003714624,0.0005662519,0.00177438,0.00006763281,0.0006149238,0.000005470863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990834,0.0002828794,0.00005258235,0.0000567331,0.000007264718,0.000003707933,0.0001052069,0.000007831643,0.0004004216],"genre_scores_gemma":[0.9993089,0.00005681902,0.00005665777,0.00002913992,0.00001170873,0.000003343907,0.0001308734,0.00000218393,0.0004003293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020409,"threshold_uncertainty_score":0.006758988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008902314845956076,"score_gpt":0.2760641169310254,"score_spread":0.2671618020850694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}