{"id":"W4411991994","doi":"10.1016/s2213-2600(25)00164-x","title":"Evidence required to evaluate the use of bacteriologically confirmed asymptomatic tuberculosis disease as a primary endpoint in prevention of tuberculosis disease vaccine licensure trials","year":2025,"lang":"en","type":"review","venue":"The Lancet Respiratory Medicine","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European and Developing Countries Clinical Trials Partnership; National Institute of Allergy and Infectious Diseases; Engineering and Physical Sciences Research Council; University of Edinburgh; Wellcome Trust","keywords":"Medicine; Licensure; Tuberculosis; Asymptomatic; Clinical endpoint; Clinical trial; Disease; Intensive care medicine; Immunology; Internal medicine; Pathology; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01438747,0.001437758,0.01181016,0.001942174,0.0002811508,0.003330546,0.002743747,0.003305775,0.005991466],"category_scores_gemma":[0.03517659,0.0009215035,0.008517921,0.002049681,0.0007832731,0.001868158,0.001030211,0.003856063,0.0007834134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001946305,"about_ca_system_score_gemma":0.004234757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003762278,"about_ca_topic_score_gemma":0.007010411,"domain_scores_codex":[0.9928625,0.003335864,0.001937178,0.0005166219,0.001137248,0.0002104784],"domain_scores_gemma":[0.9620519,0.03266793,0.003126925,0.0004794563,0.001354019,0.0003198363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002940338,0.00007670854,0.0005341037,0.7029023,0.02828218,0.0001376599,0.00009149099,0.0007030614,0.000805924,0.001874301,0.005949945,0.2557019],"study_design_scores_gemma":[0.005819723,0.001772757,0.006281696,0.6318404,0.1881529,0.0004711369,0.0001952109,0.0005692618,0.0006660443,0.005871381,0.158247,0.0001124147],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002217776,0.998668,0.0001603426,0.0002898421,0.0002415793,0.0000541788,0.0001026554,0.000006095946,0.0002555471],"genre_scores_gemma":[0.007235845,0.9904128,0.0007727212,0.0009538853,0.0002045057,0.0001175711,0.0001644971,0.000005744641,0.0001324214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01438747,"threshold_uncertainty_score":0.07608914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3911054661829074,"score_gpt":0.4811402647186569,"score_spread":0.09003479853574947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}