{"id":"W4411992249","doi":"10.1016/j.arr.2025.102823","title":"The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan","year":2025,"lang":"en","type":"article","venue":"Ageing Research Reviews","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; York University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Heart and Stroke Foundation of Canada","keywords":"Extracellular vesicles; Adiponectin; Extracellular; Vesicle; Chemistry; Cell biology; Pharmacology; Medicine; Biophysics; Internal medicine; Biology; Biochemistry; Membrane; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004776258,0.0001228235,0.0002035701,0.00005496092,0.000462133,0.00006267941,0.0003448349,0.00008474613,0.000002003433],"category_scores_gemma":[0.001686161,0.0000885035,0.0001263023,0.0001828126,0.0002672658,0.000004865217,0.0002047306,0.0001887348,0.000001396712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001629742,"about_ca_system_score_gemma":0.0001476551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000224758,"about_ca_topic_score_gemma":0.00002733597,"domain_scores_codex":[0.9980323,0.0006115173,0.0004233455,0.0003592795,0.0001489242,0.0004246728],"domain_scores_gemma":[0.998847,0.0002125337,0.0001298937,0.0005438397,0.0001833091,0.00008341171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007484422,0.00003576166,0.0001316001,0.0004842388,0.00003415198,0.000001600392,0.00003479332,6.488967e-7,0.7736936,0.0003891055,0.0004116628,0.2247081],"study_design_scores_gemma":[0.0009672802,0.0006020467,0.001898029,0.0004849681,0.0000794705,0.000006457867,0.0002493158,0.001915644,0.5954243,0.004162385,0.393973,0.0002371239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.558448,0.4338884,0.004464129,0.0009100134,0.00008643049,0.002069748,0.000005342365,0.000008371678,0.0001196276],"genre_scores_gemma":[0.9788147,0.01854892,0.001030221,0.00006528633,0.0001089126,0.0002627684,0.00001359408,0.0000217141,0.001133928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4203667,"threshold_uncertainty_score":0.3609068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03802344248587152,"score_gpt":0.3768236908399079,"score_spread":0.3388002483540363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}