{"id":"W4411995123","doi":"10.1038/s41467-025-61426-5","title":"Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; HIV Legal Network; University of British Columbia; BC Centre for Disease Control; AIDS Vancouver; Nova Scotia Health Authority; University of Manitoba","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Center for AIDS Research, University of Washington; National Institute of Allergy and Infectious Diseases; European Commission; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Case Western Reserve University; Gilead Sciences","keywords":"Doxycycline; Pre-exposure prophylaxis; Human immunodeficiency virus (HIV); Men who have sex with men; Microbiome; Medicine; Male Homosexuality; Male circumcision; Sexually active; Immunology; Syphilis; Biology; Bioinformatics; Population; Health services; Microbiology; Environmental health; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006629467,0.0001339667,0.0003602167,0.00008650839,0.0002167566,0.0003168822,0.00009606567,0.0002354661,0.001885697],"category_scores_gemma":[0.001212862,0.0001355911,0.0002877602,0.00009047965,0.0001609976,0.0002497154,0.0002400068,0.0003352536,0.0001118075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729379,"about_ca_system_score_gemma":0.0004351682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007086236,"about_ca_topic_score_gemma":0.002137572,"domain_scores_codex":[0.9996164,0.0001834682,0.00002462801,0.00006340896,0.00006103252,0.00005108024],"domain_scores_gemma":[0.9994729,0.0001704958,0.0001655193,0.00003254712,0.00004651305,0.0001121114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.08912846,0.007982058,0.2830595,0.00175551,0.001016505,0.0003654475,0.001616426,0.000838766,0.1212498,0.000153206,0.0009016519,0.4919326],"study_design_scores_gemma":[0.001734472,0.1462697,0.8291143,0.0001974668,0.0007790668,0.000436445,0.0007460366,0.0008987353,0.01590119,0.0001424603,0.003744638,0.00003543425],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989265,0.0006217884,0.00005639183,0.00004066607,0.000007889051,0.00004073831,0.00005556682,0.000001801194,0.0002487324],"genre_scores_gemma":[0.9987971,0.000360959,0.0003320733,0.00007727723,0.00001350663,0.00004475868,0.00005964094,0.000001398965,0.0003133267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885697,"threshold_uncertainty_score":0.006308258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145662344521632,"score_gpt":0.360771293579872,"score_spread":0.3462050591277088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}