{"id":"W4412001455","doi":"10.1093/ndt/gfaf114","title":"Rationale, design and baseline characteristics of REMODEL, a mechanism-of-action trial with semaglutide in people with type 2 diabetes and chronic kidney disease","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Astellas Pharma; Novo Nordisk; Pfizer; Angion; Moderna; Regeneron Pharmaceuticals; Gilead Sciences; Maze Therapeutics; Sanofi; Amgen; Horizon Pharma; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Kidney disease; Renal function; Internal medicine; Urology; Type 2 diabetes; Creatinine; Diabetes mellitus; Endocrinology; Kidney; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0218269,0.003605098,0.0042634,0.0009508382,0.001454819,0.00267906,0.001796513,0.003255863,0.01597488],"category_scores_gemma":[0.01500231,0.001646516,0.002997438,0.001355338,0.002084038,0.001903897,0.001041023,0.003461716,0.00461598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001224314,"about_ca_system_score_gemma":0.00540738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007672778,"about_ca_topic_score_gemma":0.001693975,"domain_scores_codex":[0.9863648,0.009176205,0.0009706143,0.001419119,0.001045435,0.001023751],"domain_scores_gemma":[0.9960803,0.0009389233,0.0008789601,0.000407533,0.0006970209,0.0009972298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9336789,0.007030226,0.008548652,0.006859365,0.004251547,0.0002981171,0.0002743352,0.001251091,0.002076725,0.003314463,0.007548206,0.02486847],"study_design_scores_gemma":[0.8939921,0.05619525,0.01241628,0.001638538,0.005064423,0.0001959067,0.0001500039,0.001572163,0.0007546543,0.005301111,0.02261587,0.0001036723],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.07643966,0.007861811,0.007864159,0.00421449,0.002210069,0.8799175,0.01174798,0.0002174032,0.009526933],"genre_scores_gemma":[0.09974957,0.001467369,0.01011678,0.004124572,0.000652808,0.8787699,0.002376108,0.00003063181,0.002712366],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0218269,"threshold_uncertainty_score":0.115433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102913034344134,"score_gpt":0.2383118991645874,"score_spread":0.2272827688211461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}