{"id":"W4412003093","doi":"10.1182/blood.2025029269","title":"<i>SRSF2</i>-mutated MDS: bortezomib STAT?","year":2025,"lang":"en","type":"letter","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Celgene; Sanofi; Pfizer; Bristol-Myers Squibb; Amgen","keywords":"stat; Bortezomib; Medicine; Multiple myeloma; Internal medicine; Biology; Genetics; Signal transduction; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006136944,0.0004024093,0.0005493433,0.0003016919,0.001175587,0.0009521423,0.0006034974,0.01016585,0.003216545],"category_scores_gemma":[0.002343757,0.0002434363,0.0004604296,0.0002311736,0.0008858294,0.0007512577,0.0002897277,0.008151652,0.002501039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002246142,"about_ca_system_score_gemma":0.0009458042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002310087,"about_ca_topic_score_gemma":0.004231612,"domain_scores_codex":[0.9996427,0.0001206349,0.00003967466,0.00005179148,0.00007221942,0.00007296459],"domain_scores_gemma":[0.9992276,0.0004317539,0.00005020355,0.00004204652,0.0001251053,0.0001233816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000375011,0.000134701,0.004744458,0.000117282,0.00004949754,0.0924293,0.0001650634,0.0003750634,0.003009771,0.00956925,0.8562105,0.03282014],"study_design_scores_gemma":[0.0006563024,0.0002870804,0.007705912,0.0004059792,0.0001150805,0.1302386,0.0007393207,0.005802013,0.003646827,0.04128088,0.8090429,0.00007915737],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.009773998,0.002924769,0.0004901271,0.9573283,0.01376936,0.00003628794,0.0001292732,0.0001070366,0.01544091],"genre_scores_gemma":[0.1670532,0.005089364,0.001479214,0.6993607,0.09050945,0.00009378751,0.0001670246,0.00006564899,0.03618175],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01016585,"threshold_uncertainty_score":0.01629698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005929705792180534,"score_gpt":0.2049276408512497,"score_spread":0.1989979350590692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}