{"id":"W4412003127","doi":"10.1001/jamaoncol.2025.1891","title":"First-Line Therapy For Advanced Non–Clear Cell Renal Cell Carcinoma","year":2025,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Oncology; Renal cell carcinoma; Meta-analysis; Cochrane Library; Observational study; MEDLINE; Clinical trial; Immunotherapy; Atezolizumab; Nivolumab; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066789,0.0002851571,0.0006430859,0.0002005267,0.0001324437,0.0000153692,0.0001758149,0.0003380992,0.0001867862],"category_scores_gemma":[0.00005197731,0.0002332244,0.0002787575,0.0002395767,0.00008696377,0.00005739151,0.00006897842,0.0002955394,0.00008708402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902539,"about_ca_system_score_gemma":0.000531844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006139105,"about_ca_topic_score_gemma":0.00003925695,"domain_scores_codex":[0.9983208,0.00006442372,0.0004234127,0.0005333493,0.0001623656,0.0004956869],"domain_scores_gemma":[0.9984877,0.0004476831,0.0001504249,0.0005305171,0.0002119731,0.0001717732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04245461,0.007588105,0.03851374,0.001686666,0.0004268021,0.001700261,0.001683224,0.0005273413,0.5027126,0.0005362192,0.1278976,0.2742728],"study_design_scores_gemma":[0.0314399,0.01575735,0.06116328,0.00005888252,0.0002490105,0.00003778801,0.0001881877,0.001007779,0.3914223,0.0003277215,0.4980796,0.0002682447],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9228559,0.002056988,0.001087518,0.008024007,0.0004886298,0.001801323,0.00001880542,0.00006636731,0.06360047],"genre_scores_gemma":[0.9652871,0.0003304217,0.006919592,0.003602704,0.0003301465,0.000409007,0.00007490622,0.00004499908,0.02300115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3701819,"threshold_uncertainty_score":0.9510615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000099774343196,"score_gpt":0.3031120302561916,"score_spread":0.2831110325127597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}