{"id":"W4412008193","doi":"10.1002/hem3.70352","title":"Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone Loss","year":2025,"lang":"en","type":"preprint","venue":"HemaSphere","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Active Biotech","keywords":"Erythropoiesis; Medicine; Myelodysplastic syndromes; Bone marrow; Cancer research; Anemia; Pharmacology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004351723,0.0007033736,0.0006351622,0.0006308877,0.0002376729,0.0003301301,0.000520853,0.0006586729,0.001999443],"category_scores_gemma":[0.000173183,0.000264129,0.0005394483,0.000216362,0.0003907355,0.0003236913,0.0002017601,0.001927413,0.0003656207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593797,"about_ca_system_score_gemma":0.0005684391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000561269,"about_ca_topic_score_gemma":0.001199884,"domain_scores_codex":[0.999837,0.00003662624,0.0000154439,0.00003111864,0.00003564651,0.00004402319],"domain_scores_gemma":[0.9998136,0.00002007897,0.00003700682,0.00001354761,0.00002610839,0.00008974902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01386169,0.01233007,0.0004406316,0.0006986298,0.0001504733,0.0002382256,0.00009717471,0.00173242,0.9458085,0.0007091096,0.001085267,0.02284787],"study_design_scores_gemma":[0.007236405,0.1736654,0.006159861,0.0001348909,0.0005271962,0.0005278502,0.0001360012,0.002988887,0.7920409,0.0006265654,0.01590421,0.00005181348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860951,0.00533572,0.002424552,0.0003952398,0.0002208911,0.0006992983,0.001827932,0.0002617696,0.002739695],"genre_scores_gemma":[0.982382,0.006381401,0.003226386,0.0002361908,0.00007485779,0.0008729468,0.002314803,0.0000320206,0.004479413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999443,"threshold_uncertainty_score":0.006688774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03090296219618452,"score_gpt":0.342556286757576,"score_spread":0.3116533245613915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}