{"id":"W4412013824","doi":"10.3389/fimmu.2025.1567167","title":"miR-107-enriched exosomes promote ROS/wnt/autophagy, inhibit intracellular mycobacterial growth and attenuate lung infection","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Microvesicles; Autophagy; Intracellular; Wnt signaling pathway; Lung; Intracellular parasite; Cell biology; Exosome; Cancer research; Microbiology; Biology; Immunology; Medicine; Chemistry; microRNA; Signal transduction; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773409,0.000222884,0.0002934744,0.0001678333,0.000120048,0.0005522738,0.00009834264,0.0003675822,0.0009588918],"category_scores_gemma":[0.0002309134,0.0001136982,0.0002993682,0.00009751638,0.000156422,0.0002804542,0.0002791462,0.0002784297,0.0003873308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429331,"about_ca_system_score_gemma":0.0001537325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008227749,"about_ca_topic_score_gemma":0.0001450079,"domain_scores_codex":[0.9998543,0.00003506145,0.00002190982,0.00002172966,0.00003412262,0.00003282626],"domain_scores_gemma":[0.9999307,0.00001251319,0.0000233733,0.000007445291,0.00001259674,0.00001327403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003239397,0.00005208762,0.001462911,0.000246992,0.00002149219,0.000122304,0.00003676727,0.0001010997,0.9894294,0.0003037437,0.000218827,0.00768054],"study_design_scores_gemma":[0.00003540593,0.0004282792,0.01231276,0.00005707161,0.00006107593,0.0007210603,0.00008008855,0.001108101,0.9760484,0.0001875681,0.008952085,0.000008143743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977823,0.01377572,0.005363103,0.0002898879,0.000133979,0.0000573107,0.0004886396,0.0001463153,0.001922144],"genre_scores_gemma":[0.9907619,0.003453486,0.003505583,0.000113405,0.00002938624,0.00004084504,0.0003740488,0.0000187896,0.001702511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009588918,"threshold_uncertainty_score":0.003207803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002883090580198228,"score_gpt":0.2132008368689198,"score_spread":0.2103177462887216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}