{"id":"W4412024091","doi":"10.1101/2025.06.30.662352","title":"<i>N</i> -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Ontario Genomics; National Institutes of Health; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; McGill University; North Carolina Biotechnology Center; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Broad spectrum; Cysteine protease; Alkyl; Cysteine; Protease; Spectrum (functional analysis); Class (philosophy); Chemistry; Biochemistry; Enzyme; Physics; Combinatorial chemistry; Organic chemistry; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092477,0.0003688267,0.0001664122,0.0001084116,0.00009403563,0.0002139439,0.00016876,0.0001935984,0.002012684],"category_scores_gemma":[0.00007563164,0.00008560472,0.0001460364,0.00008304937,0.0001449487,0.0002027328,0.000140272,0.0003279993,0.0005264969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513248,"about_ca_system_score_gemma":0.00015579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981292,"about_ca_topic_score_gemma":0.0005476899,"domain_scores_codex":[0.9999473,0.00001084575,0.000003617231,0.000008708989,0.00001770729,0.0000117956],"domain_scores_gemma":[0.9999715,0.000003361457,0.000009250988,0.000003364446,0.00000637755,0.00000603226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002705168,0.00007426235,0.0002206242,0.0001049823,0.00001281361,0.0001544538,0.00002160564,0.0006286281,0.9802669,0.001303669,0.0008257398,0.0161158],"study_design_scores_gemma":[0.00009061602,0.001311606,0.001065325,0.00001532483,0.00001749786,0.0003480196,0.00001671935,0.001652302,0.9741133,0.0002235706,0.02113654,0.000009164452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456949,0.01165755,0.01753781,0.000799639,0.0002022604,0.0002205956,0.0007074039,0.0003606982,0.02281914],"genre_scores_gemma":[0.97223,0.005424142,0.01012063,0.0002520462,0.00006894812,0.00006609312,0.0006138247,0.00003521972,0.01118907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012684,"threshold_uncertainty_score":0.00673306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00865248576534208,"score_gpt":0.2263653418702329,"score_spread":0.2177128561048908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}