{"id":"W4412028117","doi":"10.1101/2025.07.03.663114","title":"The accessory protein CvnF8 modulates histidine kinase activity in an Actinobacterial G protein system in <i>Streptomyces coelicolor</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of California, San Francisco; McMaster University; National Institutes of Health; National Science Foundation","keywords":"Streptomyces coelicolor; Histidine; Streptomyces; Histidine kinase; Protein kinase A; Cell biology; Chemistry; Kinase; Biochemistry; Biology; Microbiology; Genetics; Bacteria; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009503264,0.0003267381,0.0001710146,0.0001375244,0.0001364108,0.0002035348,0.0001721352,0.0001414747,0.0004801128],"category_scores_gemma":[0.0001186364,0.00006259172,0.0001579713,0.00008281607,0.0001656267,0.0001104444,0.0002267133,0.0002234982,0.0001548804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004773465,"about_ca_system_score_gemma":0.0001241063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001801626,"about_ca_topic_score_gemma":0.001726523,"domain_scores_codex":[0.9999074,0.00002045827,0.000006950839,0.00002021339,0.00001843197,0.00002650001],"domain_scores_gemma":[0.99991,0.00001269002,0.00002018341,0.000007007318,0.000008382495,0.00004181865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125655,0.00001519184,0.0005093208,0.00001202046,0.000002379522,0.00005283191,0.00001044426,0.00006078632,0.9988423,0.00002950444,0.00001456607,0.0003381962],"study_design_scores_gemma":[0.0000277807,0.0003393085,0.02698539,0.00000774712,0.00001534556,0.0002997865,0.0001051491,0.005581426,0.9652246,0.00007053016,0.001332369,0.00001057442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992705,0.0001013644,0.0002645669,0.00001443201,0.000003482667,0.000002473416,0.00003837884,0.00001683049,0.000288033],"genre_scores_gemma":[0.9993179,0.00002897873,0.0002643933,0.000007797415,0.000001358465,0.000002321217,0.0001259697,0.000004128754,0.0002472172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801626,"threshold_uncertainty_score":0.003582239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499228708912115,"score_gpt":0.2362863221332362,"score_spread":0.2212940350441151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}